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Titolo:
Temporal and spatial variations in slow axonal transport velocity along peripheral motoneuron axons
Autore:
Xu, Z; Tung, VWY;
Indirizzi:
Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 iochem, Worcester, MA 01655 USA Univ Massachusetts, Sch Med, Program Neurosci, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 urosci, Worcester, MA 01655 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 102, anno: 2001,
pagine: 193 - 200
SICI:
0306-4522(2001)102:1<193:TASVIS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; SUBUNIT NF-H; NEUROFILAMENT PROTEINS; CYTOSKELETAL PROTEINS; CYTOPLASMIC DYNEIN; TRANSGENIC MICE; RADIAL GROWTH; MOTOR-NEURONS; MOUSE MODEL; IN-VIVO;
Keywords:
neurofilament; intermediate filament; motor neuron; neurological disease; peripheral nerve; microtubule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Xu, Z Univ Massachusetts, Sch Med, Dept Mol Pharmacol & Biochem, 55 Lake Ave N, Worcester, MA 01655 USA Univ Massachusetts 55 Lake Ave N Worcester MAUSA 01655 MA 01655 USA
Citazione:
Z. Xu e V.W.Y. Tung, "Temporal and spatial variations in slow axonal transport velocity along peripheral motoneuron axons", NEUROSCIENC, 102(1), 2001, pp. 193-200

Abstract

Neuronal axons are cellular extensions that can reach more than a meter inlength. To maintain such a structure, macromolecules synthesized in cell bodies must be transported to the distal axons. Proteins associated with membranous organelles are generally transported in several fast transported groups, while cytoplasmic proteins, mostly composed of cytoskeletal proteins,are transported in slowly transported groups. Neurofilaments are a main component in the slowly transported group. Composed of three polypeptide subunits (NF-H, NF-M and NF-L), they are the most abundant cytoskeletal elementin large myelinated axons. In various neurological or neurotoxic disorders, selective accumulation of neurofilaments was observed in different compartments of a neuron (cell bodies, proximal or distal axons). The underlying mechanism for this regional selectivity has been unclear. Using the classical pulse labeling method, we examined the changes in neurofilament transport velocity in transgenic mice that overexpress different neurofilament subunits. We present evidence that at least three velocities of neurofilament transport exist along peripheral motor axons. Each of these velocities was altered differently depending on which neurofilament subunit was overexpressed. We suggest that neurofilament transport in motor axons consists of multiple successive stages and that each of these stages is carried out by different transport mechanisms. These differences provide a basis for the regionaldeficiencies in axonal transport associated with several neurological disorders. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:43:07