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Titolo:
Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: Effect of antidepressants
Autore:
Cyr, M; Morissette, M; Barden, N; Beaulieu, S; Rochford, J; Di Paolo, T;
Indirizzi:
Univ Laval, CHUQ, Mol Endocrinol Res Ctr, Quebec City, PQ, Canada Univ Laval Quebec City PQ Canada crinol Res Ctr, Quebec City, PQ, Canada Univ Laval, Fac Pharm, Quebec City, PQ, Canada Univ Laval Quebec City PQ Canada val, Fac Pharm, Quebec City, PQ, Canada Univ Laval, CHUQ, Neurosci Lab, Quebec City, PQ, Canada Univ Laval QuebecCity PQ Canada , Neurosci Lab, Quebec City, PQ, Canada Univ Laval, Fac Med, Dept Physiol, Quebec City, PQ, Canada Univ Laval Quebec City PQ Canada , Dept Physiol, Quebec City, PQ, Canada McGill Univ, Dept Psychiat, Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada
Titolo Testata:
NEUROSCIENCE
fascicolo: 1, volume: 102, anno: 2001,
pagine: 151 - 158
SICI:
0306-4522(2001)102:1<151:DAITMU>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM TREATMENT; PITUITARY-ADRENOCORTICAL SYSTEM; RAT CAUDATE-PUTAMEN; TYROSINE-HYDROXYLASE; NUCLEUS-ACCUMBENS; MOUSE MODEL; IN-VIVO; PSYCHOTIC DEPRESSION; CHRONIC FLUOXETINE; CHRONIC ESTRADIOL;
Keywords:
dopamine; fluoxetine; amitriptyline; in situ hybridization; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Di Paolo, T Univ Laval, CHUQ, Mol Endocrinol Res Ctr, Quebec City, PQ, Canada Univ Laval Quebec City PQ Canada tr, Quebec City, PQ, Canada
Citazione:
M. Cyr et al., "Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: Effect of antidepressants", NEUROSCIENC, 102(1), 2001, pp. 151-158

Abstract

Transgenic mice bearing a transgene coding for a glucocorticoid receptor antisense mRNA, which partially blocks glucocorticoid receptor expression, were used to investigate the long-term effect of hypothalamic-pituitary-adrenal axis dysfunction on brain dopamine transmission. Compared to control mice, the transgenic animals showed increased amphetamine-induced locomotor activity and increased concentrations of striatal dopamine and its metabolites dihydroxyphenylacetic acid and homovanillic acid. Binding of [H-3]SCH 23390 and [H-3]spiperone to, respectively, D1 and D2 dopamine receptors was increased in transgenic mice. In contrast, autoradiography of striatal [H-3]GBR 12935 binding to the dopamine transporter was decreased and the mRNA levels of this transporter, measured by in situ hybridization, remained unchanged in the substantia nigra pars compacta. The effect of chronic treatmentfor two weeks with amitriptyline or fluoxetine was compared in control andtransgenic mice. No significant changes were observed in control mice following antidepressant treatment, whereas in transgenic mice both antidepressants reduced striatal [H-3]SCH 23390 and [H-3]raclopride specific binding to D1 and D2 receptors. Amitriptyline, but not fluoxetine, increased striatal [H-3]GBR 12935 binding to the dopamine transporter, whereas its mRNA level in the substantia nigra pars compacta was decreased in fluoxetine, compared to vehicle- or amitriptyline-treated transgenic mice. From these results we suggest that hyperactive dopaminergic activity of the nigrostriatal pathway controls motor activity in the transgenic mice. Furthermore, antidepressant treatment corrected the increased striatal D1 and D2 receptors and decreased dopamine transporter levels in the transgenic mice. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:54:15