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Titolo:
Effect of the repeated administration of (+/-)-3,4-methylenedioxymethamphetamine on the behavioral response of rats to the 5-HT1A receptor agonist (+/-)-8-hydroxy-(di-n-propylamino)Tetralin
Autore:
Granoff, MI; Ashby, CR;
Indirizzi:
St Johns Univ, Dept Pharmaceut Sci, Jamaica, NY 11439 USA St Johns Univ Jamaica NY USA 11439 Pharmaceut Sci, Jamaica, NY 11439 USA SUNY Stony Brook, Hlth Sci Ctr, Sch Med, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Med, Stony Brook, NY 11794 USA
Titolo Testata:
NEUROPSYCHOBIOLOGY
fascicolo: 1, volume: 43, anno: 2001,
pagine: 42 - 48
SICI:
0302-282X(2001)43:1<42:EOTRAO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-METHYLENEDIOXYMETHAMPHETAMINE ECSTASY; MDMA; SEROTONIN; BRAIN; METHYLENEDIOXYMETHAMPHETAMINE; 8-OH-DPAT; 8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)TETRALIN; PHARMACOLOGY; TERMINALS; DEPLETION;
Keywords:
3,4-methylenedioxymethamphetamine; (+/-)-8-hydroxy-(di-n-propylamino)tetralin; 5-HT1A receptors; reciprocal forepaw treading; flat body posture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ashby, CR St Johns Univ, Dept Pharmaceut Sci, 8000 Utopia Pkwy, Jamaica, NY 11439 USA St Johns Univ 8000 Utopia Pkwy Jamaica NY USA 11439 NY 11439 USA
Citazione:
M.I. Granoff e C.R. Ashby, "Effect of the repeated administration of (+/-)-3,4-methylenedioxymethamphetamine on the behavioral response of rats to the 5-HT1A receptor agonist (+/-)-8-hydroxy-(di-n-propylamino)Tetralin", NEUROPSYCHB, 43(1), 2001, pp. 42-48

Abstract

In this study, we examined the effect of the subcutaneous administration (twice daily for 4 consecutive days) of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg) or saline (1 ml/kg) on the response of rats to the behavioral effects of the 5-HT1A agonist (+/-)-8-hydroxy-(di-n-propylamino)tetralin (8-OH-DPAT) 30 days after the last saline or MDMA treatment. The reciprocalforepaw treading elicited by the 0,25-mg/kg dose of 8-OH-DPAT was significantly lower in animals pretreated with MDMA compared to vehicle-treated animals. However, there were no significant differences between the MDMA- and vehicle-treated animals in flat body posture, locomotor activity and rectaltemperature measured after the systemic administration of 8-OH-DPAT. Overall, our results suggest that the depletion of 5-HT levels by the repeated administration of MDMA does not produce a supersensitivity of central 5-HT1Areceptors in the rat as determined via our approach. Copyright (C) 2001 S. Karger AG, Basel.

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Documento generato il 25/01/20 alle ore 09:44:28