Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit
Autore:
Navaneetham, D; Penn, AS; Howard, JF; Conti-Fine, BM;
Indirizzi:
Univ Minnesota, Dept Biochem Mol Biol & Biophys, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Biol & Biophys, St Paul, MN 55108 USA Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA NINDS, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892NINDS, NIH, Bethesda, MD 20892 USA Univ N Carolina, Dept Neurol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA ina, Dept Neurol, Chapel Hill, NC USA
Titolo Testata:
MUSCLE & NERVE
fascicolo: 2, volume: 24, anno: 2001,
pagine: 203 - 210
SICI:
0148-639X(200102)24:2<203:HTEISO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; MYASTHENIA-GRAVIS; ALPHA-SUBUNIT; EPITHELIAL-CELLS; GENE-EXPRESSION; ASSOCIATION; ISOFORMS; THYMOMAS; GAMMA; LINE;
Keywords:
acetylcholine receptor; autoimmunity; human; myasthenia gravis; thymus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Conti-Fine, BM Univ Minnesota, Dept Biochem Mol Biol & Biophys, 1479 Gortner Ave, St Paul, MN 55108 USA Univ Minnesota 1479 Gortner Ave St Paul MN USA 55108 08 USA
Citazione:
D. Navaneetham et al., "Human thymuses express incomplete sets of muscle acetylcholine receptor subunit transcripts that seldom include the delta subunit", MUSCLE NERV, 24(2), 2001, pp. 203-210

Abstract

In myasthenia gravis (MG) the muscle acetylcholine receptor (AChR) is the target of an immune response that might begin in the thymus. The thymus expresses binding sites for specific ligands of muscle AChR, a complex proteincomposed of alpha, beta, gamma (or epsilon) and delta subunits. The thymusexpresses the AChR cr subunit, but there is controversy regarding the expression in the thymus of the gamma, epsilon and delta subunits. We investigated the presence of messenger RNA (mRNA) for the different muscle AChR subunits in thymus tissue from 20 healthy subjects and 13 myasthenic patients, We detected mRNA for the alpha and epsilon subunits in all samples, for thebeta subunit in all but one sample and for the gamma subunit in most samples although at lower levels than the epsilon subunit. Myasthenic thymuses expressed levels of gamma subunit mRNA similar to control thymuses but more abundant epsilon subunit mRNA. None of the myasthenic thymuses and only twocontrol thymuses expressed detectable delta subunit mRNA. This supports the hypothesis that human thymus may express AChR proteins that do not include the delta subunit. Such receptors, which would have different antigenic structure than the muscle AChRs, might have a role in triggering the autoimmune response that causes MG. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:06:50