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Titolo:
Stability of adenoviral vectors following catheter delivery
Autore:
Tsui, LV; Zayek, N; Frey, D; Mello, C; Banik, G; Falotico, R; McArthur, JG;
Indirizzi:
Cell Genesys Inc, Foster City, CA 94404 USA Cell Genesys Inc Foster City CA USA 94404 Inc, Foster City, CA 94404 USA Cordis Corp, Johnson & Johnson Co, Warren, NJ 07059 USA Cordis Corp Warren NJ USA 07059 ohnson & Johnson Co, Warren, NJ 07059 USA
Titolo Testata:
MOLECULAR THERAPY
fascicolo: 1, volume: 3, anno: 2001,
pagine: 122 - 125
SICI:
1525-0016(200101)3:1<122:SOAVFC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-TRANSFER;
Keywords:
catheter; intravascular; adenovirus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Tsui, LV Cell Genesys Inc, 324 Lakeside Dr, Foster City, CA 94404 USA CellGenesys Inc 324 Lakeside Dr Foster City CA USA 94404 404 USA
Citazione:
L.V. Tsui et al., "Stability of adenoviral vectors following catheter delivery", MOL THER, 3(1), 2001, pp. 122-125

Abstract

Adenoviral vectors have shown promise in a variety of preclinical vasculardisease models. Intravascular infusion is one methodology to introduce theadenoviral vector into the affected area of the blood vessel. The biocompatibility of the infusion catheter with the adenoviral vector is key for successful local transfer. It has been recently suggested that catheter-based delivery of adenoviral vectors may result in the loss of vector infectivity. We demonstrate here a catheter capable of delivering adenoviral vectors without the loss of viral particle or infectious titers. First- (Delta E1) and second- (Delta E1/Delta E4) generation adenoviral vectors were tested for their biocompatibility with the Crescendo microporous infusion catheter, which is designed for local infusion of therapeutic agents to human coronary or peripheral arteries. We found that incubation of either the Delta E1 or the Delta E1/Delta E4 viral vectors for up to 30 min in the catheter at 37 degreesC did not result in a loss of viral particles or of viral infectivity. Here, we show that the Crescendo catheter is biocompatible with adenoviral vectors and suitable for vascular gene therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 11:46:34