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Titolo:
Expression patterns of cathepsins B, H, K, L and S in the human endometrium
Autore:
Jokimaa, V; Oksjoki, S; Kujari, H; Vuorio, E; Anttila, L;
Indirizzi:
Univ Turku, Dept Obstet & Gynecol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 t & Gynecol, FIN-20520 Turku, Finland Univ Turku, Dept Mol Biol & Med Biochem, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Med Biochem, FIN-20520 Turku, Finland Univ Turku, Dept Pathol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Pathol, FIN-20520 Turku, Finland Univ Turku, MediCity Res Lab, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 ity Res Lab, FIN-20520 Turku, Finland
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 1, volume: 7, anno: 2001,
pagine: 73 - 78
SICI:
1360-9947(200101)7:1<73:EPOCBH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; MENSTRUAL-CYCLE; MATRIX METALLOPROTEINASES; PLASMINOGEN-ACTIVATOR; STROMAL CELLS; EXTRACELLULAR-MATRIX; PROGESTERONE; DECIDUALIZATION; IMPLANTATION; INHIBITOR;
Keywords:
cathepsin; cysteine proteinases; endometrium; extracellular matrix; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Jokimaa, V Puutarhakatu 2 C 46, FIN-20100 Turku, Finland Puutarhakatu 2 C46 Turku Finland FIN-20100 00 Turku, Finland
Citazione:
V. Jokimaa et al., "Expression patterns of cathepsins B, H, K, L and S in the human endometrium", MOL HUM REP, 7(1), 2001, pp. 73-78

Abstract

Cathepsins B, H, K, L and S belong to the family of lysosomal cysteine proteinases and participate in a variety of proteolytic processes, including degradation of the extracellular matrix (ECM), In the present study, we usedNorthern hybridization to demonstrate the presence of mRNAs for cathepsinsB, H, K, L and S in human endometrium during both the proliferative and secretory phases of menstrual cycle, The mRNA levels for cathepsins H and K were significantly lower in secretory phase endometrium in comparison with proliferative phase endometrium, Immunohistochemical localization of the different cathepsins revealed widespread distribution of all cathepsins in both stroma and epithelial cells, The immunoreactivity for cathepsins B, H andK exhibited changes related to endometrial location and/or to the phase ofthe cycle, The strongest immunoreactivity for cathepsins B, H, L and S wasobserved in the surface epithelium of the endometrium, The staining for cathepsins was predominantly intracellular, but immunoreactivity was also detected on the surface of small lymphoid cells in the stroma, The findings ofthe present study suggest that cysteine cathepsins are needed for normal development and function of human endometrium during both the proliferative and secretory phases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:11:14