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Titolo:
Expression of the angiogenic growth factors VEGF, FGF-2, EGF and their receptors in normal human endometrium during the menstrual cycle
Autore:
Moller, B; Rasmussen, C; Lindblom, B; Olovsson, M;
Indirizzi:
Uppsala Univ, Sect Obstet & Gynaecol, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75185 rens Hlth, SE-75185 Uppsala, Sweden
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 1, volume: 7, anno: 2001,
pagine: 65 - 72
SICI:
1360-9947(200101)7:1<65:EOTAGF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL-CELL PROLIFERATION; MESSENGER-RNA EXPRESSION; IMMUNOHISTOCHEMICAL LOCALIZATION; ESTROGEN REGULATION; CIGARETTE-SMOKING; PLACENTA; UTERUS; EPITHELIUM; FLT-1; KDR;
Keywords:
angiogenesis; EGF; endometrium; FGF-2; VEGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Olovsson, M Uppsala Univ, Sect Obstet & Gynaecol, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75185 E-75185 Uppsala, Sweden
Citazione:
B. Moller et al., "Expression of the angiogenic growth factors VEGF, FGF-2, EGF and their receptors in normal human endometrium during the menstrual cycle", MOL HUM REP, 7(1), 2001, pp. 65-72

Abstract

Angiogenesis is an important but poorly understood process of the cycling endometrium, Endometrial angiogenesis is believed to be regulated by angiogenic growth factors under the influence of ovarian steroids. Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and VEGFR-2, fibroblast growth factor 2 (FGF-2) and its receptors FGFR-1 and FGFR-2, as well as epidermal growth factor (EGP) and its receptor EGFR are believed to be important in the control of angiogenesis in the human endometrium, Their expression was examined by immunohistochemistry in endometrial biopsies obtained from 16 healthy women with proven fertility. Western blot analysis showed that the primary antibodies used were specific for their epitopes. We found that VEGF, FGF-2, EGF and their receptors were all expressed, especially inand/or around blood vessels, thus supporting the hypothesis that these peptides contribute to the regulation of angiogenesis and blood vessel function in the human endometrium, The receptors VEGFR-1, VEGFR-2, FGFR-2 and EGFRwere co-expressed and exhibited their strongest expression during the beginning of the secretory phase, coinciding with the developing endometrial oedema and formation of a complex subepithelial capillary plexus. No correlation was seen between receptor expression and stromal blood vessel density.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:30:40