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Titolo:
Two-step regulation of left-right asymmetric expression of Pitx2: Initiation by nodal signaling and maintenance by Nkx2
Autore:
Shiratori, H; Sakuma, R; Watanabe, M; Hashiguchi, H; Mochida, K; Sakai, Y; Nishino, J; Saijoh, Y; Whitman, M; Hamada, H;
Indirizzi:
Osaka Univ, Inst Mol & Cellular Biol, Div Mol Biol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ol Biol, Suita, Osaka 5650871, Japan Japan Sci & Technol Corp, CREST, Suita, Osaka 5650871, Japan Japan Sci & Technol Corp Suita Osaka Japan 5650871 , Osaka 5650871, Japan Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 1, volume: 7, anno: 2001,
pagine: 137 - 149
SICI:
1097-2765(200101)7:1<137:TROLAE>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TGF-BETA SUPERFAMILY; HOMEOBOX GENE; HEART DEVELOPMENT; HOMEODOMAIN FACTOR; SITUS-INVERSUS; TRANSCRIPTION; PATHWAY; EMBRYOS; MICE; MORPHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Hamada, H Osaka Univ, Inst Mol & Cellular Biol, Div Mol Biol, 1-3 Yamada Oka, Suita,Osaka 5650871, Japan Osaka Univ 1-3 Yamada Oka Suita Osaka Japan 5650871 50871, Japan
Citazione:
H. Shiratori et al., "Two-step regulation of left-right asymmetric expression of Pitx2: Initiation by nodal signaling and maintenance by Nkx2", MOL CELL, 7(1), 2001, pp. 137-149

Abstract

Pitx2 is left-right (L-R) asymmetrically expressed initially in the lateral plate and later in primordial visceral organs. The transcriptional regulatory mechanisms that underlie L-R asymmetric expression of Pitx2 were investigated. Mouse Pitx2 has a left side-specific enhancer (ASE) that mediates both the initiation and maintenance of L-R asymmetric expression. This element contains three binding sites for the transcription factor FAST. The FAST binding sites function as Nodal-responsive elements and are sufficient for the initiation but not for the maintenance of asymmetric expression. The maintenance requires an Nkx2-5 binding site also present within the ASE. These results suggest that the left-sided expression of Pitx2 is directly initiated by Nodal signaling and is subsequently maintained by Nkx2. Such two-step control may represent a general mechanism for gene regulation during development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:55:38