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Titolo:
Drosophila chromosome condensation proteins topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing
Autore:
Lupo, R; Breiling, A; Bianchi, ME; Orlando, V;
Indirizzi:
San Raffaele Sci Inst, DIBIT, I-20132 Milan, Italy San Raffaele Sci Inst Milan Italy I-20132 t, DIBIT, I-20132 Milan, Italy
Titolo Testata:
MOLECULAR CELL
fascicolo: 1, volume: 7, anno: 2001,
pagine: 127 - 136
SICI:
1097-2765(200101)7:1<127:DCCPTI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BITHORAX COMPLEX; EPIGENETIC INHERITANCE; CHROMATIN STRUCTURE; RESPONSE ELEMENT; MOLECULAR-MODEL; TRITHORAX-GROUP; BINDING-SITES; GAGA-FACTOR; IN-VITRO; REPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Orlando, V San Raffaele Sci Inst, DIBIT, Via Olgettina 58, I-20132 Milan, Italy San Raffaele Sci Inst Via Olgettina 58 Milan Italy I-20132 aly
Citazione:
R. Lupo et al., "Drosophila chromosome condensation proteins topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing", MOL CELL, 7(1), 2001, pp. 127-136

Abstract

Mechanisms of cellular memory control the maintenance of cellular identityat the level of chromatin structure. We have investigated whether the converse is true; namely, if functions responsible for maintenance of chromosome structure play a role in epigenetic control of gene expression. We show that Topoisomerase II (TOPOII) and Barren (BARR) interact in vivo with Polycomb group (PcG) target sequences in the bithorax complex of Drosophila, including Polycomb response elements. In addition, we find that the PcG protein Polyhomeotic (PH) interacts physically with TOPOII and BARR and that BARRis required for Fab-7-regulated homeotic gene expression. Conversely, we find defects in chromosome segregation associated with ph mutations. We propose that chromatin condensation proteins are involved in mechanisms acting in interphase that regulate chromosome domain topology and are essential for the maintenance of gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:58:00