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Titolo:
TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast
Autore:
Wu, JS; Suka, N; Carlson, M; Grunstein, M;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USAUniv Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Columbia Univ Coll Phys & Surg, Dept Genet & Dev, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 1, volume: 7, anno: 2001,
pagine: 117 - 126
SICI:
1097-2765(200101)7:1<117:TUHHHD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SACCHAROMYCES-CEREVISIAE; TRANSCRIPTIONAL REPRESSION; IN-VITRO; COMPLEX; PROTEIN; DOMAIN; RPD3; H4; SSN6-TUP1; ACETYLTRANSFERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Grunstein, M Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles,CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 CA 90095 USA
Citazione:
J.S. Wu et al., "TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast", MOL CELL, 7(1), 2001, pp. 117-126

Abstract

TUP1 is recruited to and represses genes that regulate mating, glucose andoxygen use, stress response, and DNA damage. It is shown here that disruption of either TUP1 or histone deacetylase HDA1 causes histone H3/H2B-specific hyperacetylation next to the TUP1 binding site at the stress-responsive ENA1 promoter. It is also shown that TUP1 interacts with HDA1 in vitro. These data indicate that TUP1 mediates localized histone deacetylation throughHDA1. Interestingly, RPD3 deacetylates the ENA1 coding region, and both deacetylases contribute to ENA1 repression. However, epistasis analysis argues that only HDA1 and TUP1 are likely to function in the same pathway. Thesedata define gene and histone targets of HDA1 and illustrate the role of histone deacetylation in TUP1 repression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 09:49:46