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Titolo:
The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions
Autore:
Ferreira, MG; Cooper, JP;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Genet, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 ochem & Mol Genet, Denver, CO 80262 USA
Titolo Testata:
MOLECULAR CELL
fascicolo: 1, volume: 7, anno: 2001,
pagine: 55 - 63
SICI:
1097-2765(200101)7:1<55:TFYTPP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-STRAND BREAKS; SCHIZOSACCHAROMYCES-POMBE; TELOMERE LENGTH; SACCHAROMYCES-CEREVISIAE; CELL-CYCLE; REPAIR PATHWAYS; MATING-TYPE; DNA-REPAIR; MAINTENANCE; HOMOLOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Cooper, JP Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Genet, 4200 E 9th Ave, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave Denver CO USA 80262 , CO 80262 USA
Citazione:
M.G. Ferreira e J.P. Cooper, "The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions", MOL CELL, 7(1), 2001, pp. 55-63

Abstract

A paramount role of telomeres is to prevent chromosome fusions. The fission yeast Taz1 protein regulates diverse telomere functions but is not essential for growth under stress-free conditions. Strikingly, however, taz1(-) cells exhibit lethal telomere fusions when subjected to nitrogen starvation,a treatment that induces an uncommitted G1 state. These fusions are formedby Ku-dependent nonhomologous end joining. Fusions also occur during normal growth in taz1(-) cells that lack rad22(+), a gene involved in homologousrecombination. Our data suggest a model whereby taz1(-) telomeres are exposed to the prevailing mode of DNA repair, which is dictated by the cell cycle. Thus, Taz1 caps chromosome ends and provides the telomere-specific interaction that prevents Ku from treating telomeres as double-strand breaks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:45:21