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Titolo:
Effects by doxorubicin on the myocardium are mediated by oxygen free radicals
Autore:
Xu, MF; Tang, PL; Qian, ZM; Ashraf, M;
Indirizzi:
Univ Cincinnati, Dept Pathol & Lab Med, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Lab Med, Cincinnati, OH 45267 USA Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China Hong Kong Polytech Univ Kowloon Hong Kong Peoples R China eoples R China
Titolo Testata:
LIFE SCIENCES
fascicolo: 8, volume: 68, anno: 2001,
pagine: 889 - 901
SICI:
0024-3205(20010112)68:8<889:EBDOTM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BREAST-CANCER; BETA-ADRENERGIC RECEPTORS; PINEAL HORMONE MELATONIN; PERFUSED RAT-HEART; MEMBRANE FLUIDITY; INDUCED CARDIOMYOPATHY; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; ADRIAMYCIN; CELLS;
Keywords:
melatonin; doxorubicin; beta-adrenergic receptor; lipid peroxidation; reactive oxygen species; membrane permeability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Ashraf, M Univ Cincinnati, Dept Pathol & Lab Med, 231 Bethesda Ave, Cincinnati, OH 45267 USA Univ Cincinnati 231 Bethesda Ave Cincinnati OH USA 45267267 USA
Citazione:
M.F. Xu et al., "Effects by doxorubicin on the myocardium are mediated by oxygen free radicals", LIFE SCI, 68(8), 2001, pp. 889-901

Abstract

We hypothesized that doxorubicin (DOX) induces cardiotoxicity of myocardium via oxygen radicals. The present study is aimed at examining the membranealterations by oxygen radicals generated by DOX in adult rats and culturedneonatal myocytes. Our results showed that DOX 1) decreased beta -adrenoceptor (BAR) density in the cell membrane, 2) increased the membrane permeability of cultured neonatal rat myocytes and 3) altered the ultrastructure ofmyofibrils and subplasmalemmal actin networks. These effects were reproducible by exogenous hydrogen peroxide. The antioxidant melatonin (MLT) inhibited enzyme leakage and peroxidation in a concentration-dependent manner. Itis concluded that DOX induces cardiotoxicity through lipid peroxidation and melatonin is an effective antioxidant against the reactive oxygen intermediates generated by DOX. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:04:17