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Titolo:
Homing-associated cell adhesion molecule (H-CAM/CD44) on human CD34(+) hematopoietic progenitor cells
Autore:
Deguchi, T; Komada, Y;
Indirizzi:
Mie Univ, Sch Med, Dept Pediat, Tsu, Mie 5148507, Japan Mie Univ Tsu Mie Japan 5148507 Med, Dept Pediat, Tsu, Mie 5148507, Japan
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 1-2, volume: 40, anno: 2000,
pagine: 25 -
SICI:
1042-8194(200012)40:1-2<25:HCAM(O>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYALURONIC-ACID BINDING; TRANSMEMBRANE GLYCOPROTEIN GP85; HUMAN PERIPHERAL-BLOOD; ACUTE MYELOID-LEUKEMIA; COLONY-FORMING CELLS; MARROW STROMAL CELLS; RECEPTOR CD44; STEM-CELLS; T-CELL; B-CELLS;
Keywords:
CD44; hematopoetic progenitor cells; hematopoiesis; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
101
Recensione:
Indirizzi per estratti:
Indirizzo: Komada, Y Mie Univ, Sch Med, Dept Pediat, 2-174 Edobashi, Tsu, Mie 5148507, Japan Mie Univ 2-174 Edobashi Tsu Mie Japan 5148507 Mie 5148507, Japan
Citazione:
T. Deguchi e Y. Komada, "Homing-associated cell adhesion molecule (H-CAM/CD44) on human CD34(+) hematopoietic progenitor cells", LEUK LYMPH, 40(1-2), 2000, pp. 25

Abstract

Human CD34(+) hematopoietic progenitor cells (HPCs) express CD44 and can directly adhere to hyaluronate (HA) via CD44. Furthermore, CD44 may also be involved in the regulation of CD34(+) HPC proliferation and development. The expression of CD44 molecules on CD34(+) hematopoietic progenitor cells issignificantly lower on bone marrow (BM) CD34(+) cells compared with circulating CD34(+) cells in cord blood and peripheral blood. Myeloid and erythroid progenitor cells are found predominantly in CD34(+)CD44(+) cell fractions. More interestingly, CD34(+)CD44(+) cells expressing B-lymphocyte-associated CD10 and CD19 would represent unique B-lymphocyte committed precursors in the BM, which might undergo apoptotic cell death in the early steps of B-cell differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 09:58:37