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Titolo: Estimates of appropriate number of rats: interaction with housing environment
Autore: Mering, S; KalisteKorhonen, E; Nevalainen, T;
 Indirizzi:
 Univ Kuopio, Natl Lab Anim Ctr, FIN70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN70211 Anim Ctr, FIN70211 Kuopio, Finland
 Titolo Testata:
 LABORATORY ANIMALS
fascicolo: 1,
volume: 35,
anno: 2001,
pagine: 80  90
 SICI:
 00236772(200101)35:1<80:EOANOR>2.0.ZU;2O
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 WISTAR RATS;
 Keywords:
 enrichment; cage type; group size; variation; organ weights; rat;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Agriculture,Biology & Environmental Sciences
 Life Sciences
 Citazioni:
 11
 Recensione:
 Indirizzi per estratti:
 Indirizzo: Mering, S Univ Kuopio, Natl Lab Anim Ctr, POB 1627, FIN70211 Kuopio, Finland Univ Kuopio POB 1627 Kuopio Finland FIN70211 1 Kuopio, Finland



 Citazione:
 S. Mering et al., "Estimates of appropriate number of rats: interaction with housing environment", LAB ANIMALS, 35(1), 2001, pp. 8090
Abstract
An extensive list of physiological parameters from previous experiments was reanalysed in order to evaluate the effects of enrichment, cage type andgroup size on the withingroup variation and hence on the number of animals needed in studies using Wistar rats. The independent factors studied in these experiments included the provision of aspen gnawing blocks for enrichment, solid bottom cages (SBCs) and grid floor cages (GFCs) and animal number per cage (varied from 14). SOLO power analysis was used to calculate thesmallest number of animals (n) needed to detect an arbitrarily chosen 20% effect size, when significance was set at P = 0.05 and statistical power at0.90. N ratios (n(larger)/n(smaller)) were calculated for the effect of enrichment, cage type and group size to compare the 'treatment group' with the 'control group'. The n values of adrenal gland, interscapular brown adipose tissue (BAT) and epididymal adipose tissue (EAT) weights seemed to vary most, whereas final body weight (FBW) and growth seemed to be the least variable ones. According to onesample ttest, the N ratios of most physiological parameters differed significantly from zero (except the ones of FBW) indicating that n values in 'treatment' and 'control' groups were unequal. The results indicate that some of the physiological parameters are susceptible to variability attributable to environmental modifications in general whereas some are not. Furthermore, they suggest that the variation of different parameters may vary from one experiment to another and between different environments thus hindering the estimations of appropriate number of animals.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:26:30