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Titolo:
Interferon therapy in haemodialysis patients with acute hepatitis C virus infection and factors that predict response to treatment
Autore:
Gursoy, M; Gur, G; Arslan, H; Ozdemir, N; Boyacioglu, S;
Indirizzi:
Baskent Univ, Fac Med, Dept Gastroenterol, TR-06490 Ankara, Turkey BaskentUniv Ankara Turkey TR-06490 stroenterol, TR-06490 Ankara, Turkey Baskent Univ, Fac Med, Dept Microbiol, TR-06490 Ankara, Turkey Baskent Univ Ankara Turkey TR-06490 t Microbiol, TR-06490 Ankara, Turkey Baskent Univ, Fac Med, Dept Nephrol, TR-06490 Ankara, Turkey Baskent UnivAnkara Turkey TR-06490 ept Nephrol, TR-06490 Ankara, Turkey
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 70 - 77
SICI:
1352-0504(200101)8:1<70:ITIHPW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-B-HEPATITIS; RANDOMIZED CONTROLLED TRIAL; CHRONIC NON-A; HEMODIALYSIS-PATIENTS; VIRAL-HEPATITIS; RECOMBINANT INTERFERON-ALPHA-2B; LIVER-DISEASE; BLOOD-DONORS; ALPHA; METAANALYSIS;
Keywords:
acute hepatitis C virus infection; genotype; interferon; quasispecies; viral load;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gursoy, M Gastroenterol Bolumu, 1 Cadde,16 Sokak,11 Daire 5, TR-06490 Ankara, Turkey Gastroenterol Bolumu 1 Cadde,16 Sokak,11 Daire 5 Ankara Turkey TR-06490
Citazione:
M. Gursoy et al., "Interferon therapy in haemodialysis patients with acute hepatitis C virus infection and factors that predict response to treatment", J VIRAL HEP, 8(1), 2001, pp. 70-77

Abstract

In view of the high rate of chronicity of acute hepatitis C and the low efficacy of interferon (IFN) treatment in advanced liver disease, it may be beneficial to treat patients during the acute phase of the infection. Here we assessed the effects of variable-dose IFN alpha -2b treatment in haemodialysis patients with acute hepatitis C virus (HCV) infection, and identifiedfactors that may predict response to this therapy. The study population included 67 patients, but 14 were excluded due to side-effects or because they were lost to follow-up. Seventeen patients who received no specific treatment were used as controls (Group 1). Sixteen and 20 patients received low-(3 MU) and high-dose (6-10 MU) IFN alpha -2b three times weekly for 3 months (Groups 2 and 3, respectively). Virological end-of-treatment response (ETR) was observed in 1 (5.6%), 13 (56.5%), and 17 (65.4%) patients in Groups 1, 2, and 3, respectively, and virological sustained response (SR) was observed in 1 (5.6%), 6 (26.1%), and 13 (50%) patients in the three groups. Therates of virological ETR and SR in the treated groups were significantly higher than those of the control group (P < 0.01 for all comparisons). In multivariate logistic regression analysis, single stranded confirmational polymorphysm (SSCP) band number (P=0.02) was the only factor that was significantly associated with virological SR. In conclusion, IFN-alpha treatment initiated during the acute phase of HCV infection is associated with a higherrate of virological ETR and SR. This study suggested that quasispecies heterogeneity has predictive value with regard to virological SR.

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Documento generato il 22/01/20 alle ore 18:27:18