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Titolo:
Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection
Autore:
Hu, KQ; Vierling, JM; Redeker, AG;
Indirizzi:
Loma Linda Univ, Med Ctr, Dept Med, Loma Linda, CA 92354 USA Loma Linda Univ Loma Linda CA USA 92354 ept Med, Loma Linda, CA 92354 USA Jerry L Pettis Mem Vet Affairs Med Ctr, Loma Linda, CA USA Jerry L Pettis Mem Vet Affairs Med Ctr Loma Linda CA USA a Linda, CA USA Univ Calif Los Angeles, Cedars Sinai Med Ctr, Ctr Liver Dis & Transplantat, Los Angeles, CA 90048 USA Univ Calif Los Angeles Los Angeles CA USA 90048 Los Angeles, CA 90048 USA Univ So Calif, Sch Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 ver Dis, Los Angeles, CA 90033 USA
Titolo Testata:
JOURNAL OF VIRAL HEPATITIS
fascicolo: 1, volume: 8, anno: 2001,
pagine: 1 - 18
SICI:
1352-0504(200101)8:1<1:VHAIFM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVITY-DETERMINING REGION; LONG-TERM RESPONSE; BLOOD MONONUCLEAR-CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX; NONSTRUCTURAL 5A PROTEIN; AMINO-ACID SUBSTITUTIONS; RECEPTOR MESSENGER-RNA; 5' UNTRANSLATED REGION; T-LYMPHOCYTE RESPONSE; CIRRHOSIS TYPE-C;
Keywords:
hepatitis C virus; treatment of chronic hepatitis C; interferon therapy; viral level; viral quasispecies; immune response;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
226
Recensione:
Indirizzi per estratti:
Indirizzo: Hu, KQ Loma Linda Univ, Med Ctr, Inst Transplantat, 11234 Anderson St,Room1405, Loma Linda, CA 92354 USA Loma Linda Univ 11234 Anderson St,Room 1405Loma Linda CA USA 92354
Citazione:
K.Q. Hu et al., "Viral, host and interferon-related factors modulating the effect of interferon therapy for hepatitis C virus infection", J VIRAL HEP, 8(1), 2001, pp. 1-18

Abstract

The estimated prevalence of hepatitis C virus infection in the US is approximately 1.8%. Although interferon monotherapy and combination therapy of interferon with ribavirin represent mainstay for treating HCV infection, therate of sustained virologic response remains suboptimal. The growing evidence suggested that the clinical sequence and treatment response of chronic hepatitis C are determined by a dynamic, complex tripartite relationship among HCV infection, the host immune response, and the effect of different interferon regimens. The treatment response is associated with various viral factors including the pretreatment viral level, dynamic change of viral level during treatment, viral genotype quasispecies and nucleotide mutation innonstructural protein 5A of hepatitis C virus. Host factors that may affect treatment response include age, gender, race, HLA alleles and the host immune responses. Interferon regimens, including type, dose, frequency and duration of treatment and combination of interferon with other anti-HCV agents also alter the therapeutic response. Understanding these complicated interaction may provide better insights into the mechanism(s) of interferon response, leading to more effective clinical application of interferon therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:08:19