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Titolo:
Exposure of inuit in Greenland to organochlorines through the marine diet
Autore:
Bjerregaard, P; Dewailly, E; Ayotte, P; Pars, T; Ferron, L; Mulvad, G;
Indirizzi:
Natl Inst Publ Hlth, Sect Res Greenland, DK-2100 Copenhagen O, Denmark Natl Inst Publ Hlth Copenhagen Denmark O , DK-2100 Copenhagen O, Denmark Univ Laval, Dept Social & Prevent Med, Quebec City, PQ, Canada Univ LavalQuebec City PQ Canada & Prevent Med, Quebec City, PQ, Canada Natl Inst Publ Hlth, Sect Res Greenland, Nuuk, Greenland Natl Inst Publ Hlth Nuuk Greenland Sect Res Greenland, Nuuk, Greenland Quebec Toxicol Ctr, Quebec City, PQ, Canada Quebec Toxicol Ctr Quebec City PQ Canada ol Ctr, Quebec City, PQ, Canada Primary Hlth Clin, Nuuk, Greenland Primary Hlth Clin Nuuk GreenlandPrimary Hlth Clin, Nuuk, Greenland
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
fascicolo: 2, volume: 62, anno: 2001,
pagine: 69 - 81
SICI:
1528-7394(200101)62:2<69:EOIIGT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCHLORINATED-BIPHENYLS; BIRTH-WEIGHT; GESTATIONAL-AGE; HUMAN PLASMA; CHILDREN; IDENTIFICATION; CONSUMPTION; RISK; PCBS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bjerregaard, P Natl Inst Publ Hlth, Sect Res Greenland, Svanemollevej 25, DK-2100 Copenhagen O, Denmark Natl Inst Publ Hlth Svanemollevej 25 Copenhagen Denmark O
Citazione:
P. Bjerregaard et al., "Exposure of inuit in Greenland to organochlorines through the marine diet", J TOX E H A, 62(2), 2001, pp. 69-81

Abstract

High organochlorine concentrations have been found among the Inuit in eastern Canada and in Greenland. The present study was undertaken to assess theexposure to organochlorines in relation to age, sex, and diet in a generalpopulation sample of Inuit from Greenland. Survey data and plasma concentrations of 14 polychlorinated biphenyl ( PCB) congeners and 16 pesticides, including 5 toxaphene congeners, were recorded in a random population surveyof 408 adult indigenous Greenlanders. In a two-stage design, the survey response rate was 66%, and 90% of those randomly selected for blood testing participated. This was equivalent to an overall response rate of 59%. The median plasma concentration of the sum of PCB congeners was 13.3 mug/L; the lipid-adjusted value was 2109 mug/kg. The PCB concentration was twice as high as among the Inuit of Nunavik, Canada, 25 times higher than in a control group from southern Canada, and several times higher than the values found in European studies. Concentrations were similarly elevated for all PCB congeners and pesticides. The PCB congener pattern was similar to previous observations from the eastern Canadian Arctic and Greenland. Concentrations showed statistically significant positive associations with age, marine diet,and male sex in multiple linear regression analyses. The exceptionally high plasma concentrations of several organochlorines among the Inuit of Greenland are attributed to a lifelong high intake of seafood, in particular marine mammals. Concentrations of PCB adjusted for the consumption of marine food increased until approximately 40 yr of age, which is equivalent to the birth cohorts of the early 1950s. The age pattern indicates that bioaccumulation of PCB started in the 1950s, which is a likely date for the introduction of the compounds into the Arctic environment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:29:54