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Titolo:
Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome
Autore:
Trojan, DA; Collet, JP; Pollak, MN; Shapiro, S; Jubelt, B; Miller, RG; Agre, JC; Munsat, TL; Hollander, D; Tandan, R; Robinson, A; Finch, L; Ducruet, T; Cashman, NR;
Indirizzi:
McGill Univ, Ctr Hlth, Montreal Neurol Hosp, Dept Neurol, Montreal, PQ H3A2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 eurol, Montreal, PQ H3A2B4, Canada McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Inst, Montreal, PQ H3A 2B4, Canada McGill Univ, Ctr Hlth, Montreal Neurol Hosp, Dept Physiotherapy, Montreal,PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 erapy, Montreal,PQ H3A 2B4, Canada McGill Univ, Jewish Gen Hosp, Randomized Clin Trial Unit, Montreal, PQ, Canada McGill Univ Montreal PQ Canada zed Clin Trial Unit, Montreal, PQ, Canada McGill Univ, Jewish Gen Hosp, Dept Oncol, Montreal, PQ, Canada McGill Univ Montreal PQ Canada en Hosp, Dept Oncol, Montreal, PQ, Canada McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Epidemiol & Biostat, Montreal, PQ, Canada SUNY Hlth Sci Ctr, Dept Neurol, New York, NY USA SUNY Hlth Sci Ctr New York NY USA Sci Ctr, Dept Neurol, New York, NY USA Calif Pacific Med Ctr, Dept Neurol, San Francisco, CA 94115 USA Calif Pacific Med Ctr San Francisco CA USA 94115 Francisco, CA 94115 USA Univ Wisconsin, Dept Rehabil Med, Madison, WI USA Univ Wisconsin Madison WI USA sconsin, Dept Rehabil Med, Madison, WI USA Tufts Univ, New England Med Ctr, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 New England Med Ctr, Boston, MA 02111 USA Univ Vermont, Dept Neurol, Burlington, VT USA Univ Vermont Burlington VT USA Vermont, Dept Neurol, Burlington, VT USA Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON, Canada Univ Toronto Toronto ON Canada s Neurodegenerat Dis, Toronto, ON, Canada Univ Toronto, Sunnybrook Hosp, Toronto, ON, Canada Univ Toronto Toronto ON Canada nto, Sunnybrook Hosp, Toronto, ON, Canada
Titolo Testata:
JOURNAL OF THE NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 182, anno: 2001,
pagine: 107 - 115
SICI:
0022-510X(20010101)182:2<107:SIGF(D>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; POLIOMYELITIS SURVIVORS; POSTPOLIO SYNDROME; BODY-COMPOSITION; MOTOR UNIT; PROGRESSION; MULTICENTER; PROTEIN-3; HORMONE; TRIAL;
Keywords:
poliomyelitis; insulin-like growth factor-I; quality of life; strength; body mass index; fatigue;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Trojan, DA McGill Univ, Ctr Hlth, Montreal Neurol Hosp, Dept Neurol, Montreal, PQ H3A2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 real, PQ H3A2B4, Canada
Citazione:
D.A. Trojan et al., "Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome", J NEUR SCI, 182(2), 2001, pp. 107-115

Abstract

Objectives and background: To determine if serum insulin-like growth factor-I (IGF-I) levels are associated with strength, body mass index (BMI), fatigue, or quality of life in post-poliomyelitis syndrome (PPS). PPS is Likely due to a distal disintegration of enlarged post-polio motor units as a result of terminal axonal sprouting. Age-related decline in growth hormone and IGF-I (which support terminal axonal sprouts) is proposed as a contributing factor. Methods: As part of the North American Post-Poliomyelitis Pyridostigmine Study (NAPPS), baseline data on maximum voluntary isometric contraction (MVIC), BMI, subjective fatigue (fatigue severity scale, Hare fatiguesymptom scale), health-related quality of Life (short form health survey-36; SF-36), and serum IGF-I levels were gathered on 112 PPS patients. Pearson correlation coefficients were calculated to evaluate the association between serum IGF-I and MVIC in 12 muscles, BMI, two fatigue scales, and SF-36 scale scores. Results: There is a significant inverse correlation of IGF-I levels with MVIC in left ankle dorsiflexors (r=-0.30, P<0.01), and left andright knee extensors (r=-0.22, -0.25, P=<0.01, 0.01), but no significant correlations in other muscles. When men and women were evaluated separately,inverse correlations of IGF-I levels with MVIC were found only in men. IGF-I correlated inversely with BMI (r=-0.32, P=0006) and age (r=-0.32, P=0.0005). IGF-I did not correlate with the fatigue or SF-36 scales. Conclusions:In this exploratory study, we found that contrary to our expectations, IGF-I did not correlate positively with strength. IGF-I correlated negatively with strength in several lower extremity muscles, BMI, and age. IGF-I is likely not an important factor in the pathogenesis of fatigue and in determining quality of life in PPS, but its role on strength should be studied further. (C) 2001 Elsevier Science BN. All rights reserved.

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Documento generato il 22/09/20 alle ore 21:48:53