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Titolo:
HMT REGULATES HISTAMINE-INDUCED GLYCOCONJUGATE SECRETION FROM HUMAN AIRWAYS IN-VITRO
Autore:
IROKAWA T; NAGAKI M; SHIMURA S; SASAKI T; YAMAYA M; YAMAUCHI K; SHIRATO K;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT INTERNAL MED,AOBA KU,1-1 SEIRYO MACHI SENDAIMIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT INTERNAL MED,AOBA KU SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
Respiration physiology
fascicolo: 3, volume: 108, anno: 1997,
pagine: 233 - 240
SICI:
0034-5687(1997)108:3<233:HRHGSF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-METHYLTRANSFERASE; TRACHEAL EPITHELIUM; SUBMUCOSAL GLANDS;
Keywords:
AIRWAYS, MUCUS SECRETION; ENZYMES, HISTAMINE N-METHYLTRANSFERASE; GLANDS, SUBMUCOSAL, SECRETION; MAMMALS, HUMANS; MEDIATORS, HISTAMINE; MEDIATORS, PGE(2); MUCUS, SECRETION, AIRWAYS, REGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
T. Irokawa et al., "HMT REGULATES HISTAMINE-INDUCED GLYCOCONJUGATE SECRETION FROM HUMAN AIRWAYS IN-VITRO", Respiration physiology, 108(3), 1997, pp. 233-240

Abstract

To determine whether histamine N-methyltransferase (HMT) regulates mucus glycoprotein (MGP) secretion from airways, we examined the effect of an HMT inhibitor, SKF 91488, on MGP secretion from human airways invitro. MGP secretion from human airway explants (with epithelium) andisolated submucosal glands was estimated by measuring trichloroaceticacid (TCA) precipitable glycoconjugates using secretory indices. Histamine induced significant MGP secretion from both explants and isolated glands. Pretreatment with SKF 91488 significantly inhibited histamine-induced secretion from explants, while it did not alter significantly the secretion from isolated glands. H-1-blocker significantly reversed the inhibition by SKF 91488 of the secretion from explants, while H-2-blocker abolished histamine-induced secretion from both explants and isolated glands. Prostaglandin E-2 (PGE(2)) significantly inhibited histamine-induced secretion from isolated glands. The inhibitory action of SKF 91488 in airway explants was blocked by indomethacin and was significantly reduced by a prostanoid EP4 receptor antagonist (AH23848B). These findings suggest that HMT regulates MGP secretion from humanairway submucosal glands through an interaction with epithelial cellswhich involves the release of PGE(2). (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 05:21:16