Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FREQUENT OCCURRENCE OF CYP2D6 GENE DUPLICATION IN SAUDI-ARABIANS
Autore:
MCLELLAN RA; OSCARSON M; SEIDEGARD J; EVANS DAP; INGELMANSUNDBERG M;
Indirizzi:
KAROLINSKA INST,INST ENVIRONM MED,DIV MOL TOXICOL S-17177 STOCKHOLM SWEDEN KAROLINSKA INST,DEPT MED BIOCHEM & BIOPHYS STOCKHOLM SWEDEN ASTRO DRACO AB LUND SWEDEN RIYADH ARMED FORCES HOSP RIYADH SAUDI ARABIA
Titolo Testata:
Pharmacogenetics
fascicolo: 3, volume: 7, anno: 1997,
pagine: 187 - 191
SICI:
0960-314X(1997)7:3<187:FOOCGD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-P450 CYP2D6; POOR METABOLIZERS; EUROPEAN POPULATION; MOLECULAR-BASIS; DEBRISOQUINE; HYDROXYLATION; POLYMORPHISM; CHINESE; LOCUS; AMPLIFICATION;
Keywords:
SAUDI ARABIA; CYTOCHROME P450; CYP2D LOCUS; GENE DUPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Mclellan et al., "FREQUENT OCCURRENCE OF CYP2D6 GENE DUPLICATION IN SAUDI-ARABIANS", Pharmacogenetics, 7(3), 1997, pp. 187-191

Abstract

The polymorphic cytochrome P450 2D6 (CYP2D6)double dagger causing poor extensive or ultrarapid metabolism of several clinically important drugs exhibits pronounced interethnic variation, Ultrarapid metabolism is caused by multiple copies of active CYP2D6 genes and recently 29%, of an Ethiopian population has been shown to carry duplicated or multiduplicated CYP2D6 genes, whereas the corresponding frequency in other black, Oriental and European populations investigated is 1-2%. In order to characterize the distribution of alleles with multiple CYP2D6 copies in a neighbouring population and to characterize the CYP2D Locus in general among Saudi Arabians, the CYP2D6 genotype of a Saudi Arabianpopulation was examined using restriction fragment length polymorphism (RFLP) analysis and allele-specific polymerase chain reaction (PCR) amplification, Of 101 Saudi Arabians studied, 21 subjects had an EcoRIfragment indicative of CYP2D6 gene duplication, In contrast, only twoindividuals were heterozygous for a deletion of the whole gene (CYP2D65), The allele frequency of CYP2D6*4, the most common defective allele among Caucasians, was only 3.5%, in the Saudi population, Two otheralleles, CYP2D610 and *17, common in certain populations and which cause diminished enzyme activity, were found only at low allele frequencies of 3.0%, each, These findings are in agreement with earlier SaudiArabian phenotyping studies which reported a low frequency (1-2%) of poor metabolizers for CYP2D6 probe drugs. In conclusion, the Saudi Arabian population studied exhibited very few defective alleles and a large number of subjects carried duplicated CYP2D6 genes, implying a highconservation on functional CYP2D6 genes possibly due to dietary reasons and reveal the Saudi Arabians as an unique population in comparisonwith others examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:56:43