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Titolo:
Dammarane derivatives protect cultured rat cortical cells from glutamate-induced neurotoxicity
Autore:
Kim, SR; Sung, SH; Kwon, SW; Park, JH; Huh, H; Kim, YC;
Indirizzi:
Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 harm, Seoul 151742, South Korea
Titolo Testata:
JOURNAL OF PHARMACY AND PHARMACOLOGY
fascicolo: 12, volume: 52, anno: 2000,
pagine: 1505 - 1511
SICI:
0022-3573(200012)52:12<1505:DDPCRC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN ISCHEMIA; NERVOUS-SYSTEM; NEURODEGENERATION; HYPOTHESIS; DAMAGE; GROWTH; ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, YC Seoul Natl Univ, Coll Pharm, San 56-1, Seoul 151742, South Korea Seoul Natl Univ San 56-1 Seoul South Korea 151742 42, South Korea
Citazione:
S.R. Kim et al., "Dammarane derivatives protect cultured rat cortical cells from glutamate-induced neurotoxicity", J PHARM PHA, 52(12), 2000, pp. 1505-1511

Abstract

We previously reported that ginsenosides Rb-1 and Rg(3), dammarane glycosides, of Panax ginseng C. A. Meyer (Araliaceae), significantly attenuated glutamate-induced neurotoxicity in primary cultures of rat cortical cells. Toseek more potent neuroprotective compounds, we attempted to modify the chemical structure of dammarane glycosides and obtained six derivatives, MA-11, PT-11, PT-111, POA-101, POA-111 and N-001. The neuroprotective activity of these dammarane derivatives were evaluated employing primary cultures of rat corticoid cells. The glutamate-induced neuronal cell damage was significantly reduced by a pre-treatment with protopanaxadiol, MA-11 or PT-11 at concentrations ranging from 100 nM to 10 muM. Both MA-11 and PT-11, preserved the levels of catalase and inhibited decreases in glutathione reductase in glutamate-injured cells. Furthermore, the dammarane derivatives reduced the content of intracellular peroxide in glutamate-intoxicated cells. Finally, they inhibited the formation of malondialdehyde, a compound produced during lipid peroxidation, in glutamate-insulted cells. These results show that the dammarane derivatives, MA-11 and PT-11. exert significant neuroprotective effects on cultured cortical cells by a mechanism seemingly distinct from that afforded by ginsenosides Rb-1 and Rg(3). Assuch, the dammarane derivatives may be efficacious in protecting neurons from oxidative damage caused by exposure to excess glutamate.

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Documento generato il 30/09/20 alle ore 11:41:54