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Titolo:
17-beta-estradiol affects brain protein synthesis rate in ovariectomized female rats
Autore:
Hayase, K; Tanaka, M; Tujioka, K; Hirano, E; Habuchi, O; Yokogoshi, H;
Indirizzi:
Aichi Univ Educ, Dept Home Econ, Aichi 4488542, Japan Aichi Univ Educ Aichi Japan 4488542 Dept Home Econ, Aichi 4488542, Japan Aichi Univ Educ, Dept Life Sci, Aichi 4488542, Japan Aichi Univ Educ Aichi Japan 4488542 Dept Life Sci, Aichi 4488542, Japan Univ Shizouka, Sch Food & Nutr Sci, Lab Nutr Biochem, Shizouka 4228526, Japan Univ Shizouka Shizouka Japan 4228526 tr Biochem, Shizouka 4228526, Japan
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 1, volume: 131, anno: 2001,
pagine: 123 - 126
SICI:
0022-3166(200101)131:1<123:1ABPSR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC POLYRIBOSOME PROFILES; GENE-EXPRESSION; AGED RATS; QUALITY; MUSCLE; GROWTH; SKELETAL; TURNOVER; QUANTITY; LIVER;
Keywords:
17-beta-estradiol; ovariectomy; protein synthesis; brain; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hayase, K Aichi Univ Educ, Dept Home Econ, Aichi 4488542, Japan Aichi UnivEduc Aichi Japan 4488542 Econ, Aichi 4488542, Japan
Citazione:
K. Hayase et al., "17-beta-estradiol affects brain protein synthesis rate in ovariectomized female rats", J NUTR, 131(1), 2001, pp. 123-126

Abstract

The purpose of this study was to determine whether 17-beta -estradiol affects the rate of brain protein synthesis in ovariectomized female rats. Experiments were conducted on three groups of 12-wk-old female rats: group 1 were ovariectomized to reduce the level of plasma estradiol, group 2 were ovariectomized and treated with estradiol and group 3 were sham-operated controls. The fractional rates of protein synthesis in brain of ovariectomized rats treated with estradiol were significantly greater than that in ovariectomized rats without estradiol treatment. In the cerebral cortex and cerebellum, the RNA activity [g protein synthesized/(g RNA . d)] significantly correlated (r > 0.87, P < 0.001) with the fractional rate of protein synthesis. The RNA concentration (mg RNA/g protein) was not related to the fractional rate of protein synthesis in any organ. The results suggest that estrogentreatment of ovariectomized female rats is likely to increase the rate of protein synthesis in the brain and that RNA activity is at least in part related to the fractional rate of brain protein synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:30:36