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Titolo:
Cognitive and motor functions of iodine-deficient but euthyroid children in Bangladesh do not benefit from iodized poppy seed oil (Lipiodol)
Autore:
Huda, SN; Grantham-McGregor, SM; Tomkins, A;
Indirizzi:
Inst Child Hlth, Ctr Int Child Hlth, London WC1N 1EH, England Inst Child Hlth London England WC1N 1EH d Hlth, London WC1N 1EH, England Univ Dhaka, Inst Nutr & Food Sci, Dhaka 1000, Bangladesh Univ Dhaka Dhaka Bangladesh 1000 Nutr & Food Sci, Dhaka 1000, Bangladesh
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 1, volume: 131, anno: 2001,
pagine: 72 - 77
SICI:
0022-3166(200101)131:1<72:CAMFOI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDEMIC CRETINISM; SCHOOL-CHILDREN; HYPOTHYROIDISM; PERFORMANCE; INFECTIONS;
Keywords:
iodine deficiency disorders; iodized poppy seed oil; cognitive functions; school children; urinary iodine excretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Grantham-McGregor, SM Inst Child Hlth, Ctr Int Child Hlth, 30 Guilford St,London WC1N 1EH, England Inst Child Hlth 30 Guilford St London England WC1N 1EH
Citazione:
S.N. Huda et al., "Cognitive and motor functions of iodine-deficient but euthyroid children in Bangladesh do not benefit from iodized poppy seed oil (Lipiodol)", J NUTR, 131(1), 2001, pp. 72-77

Abstract

Iodine supplementation before pregnancy in iodine-deficient women preventscretinism and neuromotor deficits in their offspring. It is unclear whether iodine supplementation benefits cognitive function in iodine-deficient school-aged children. We therefore conducted a double-blind, randomized, controlled trial of the effects of iodized poppy seed oil (Lipiodol) on cognitive and motor function and weight gain of iodine-deficient school children. The study was conducted with 305 children in grades 1 and 2 from 10 primaryschools in two iodine-deficient areas in Bangladesh. The children were stratified by school and grade and randomly assigned to receive 400 mg of oralLipiodol or a placebo. All children were given a battery of cognitive and motor function tests and had their weights, serum thyroxine (T-4) and thyroid-stimulating hormone (TSH) and urinary iodine levels measured before and 4 mo after the intervention. On enrollment, both groups were moderately iodine deficient (median urinary iodine values: placebo group = 3.3 mu mol/L, n = 148; iodine group = 3.1 mu mol/L, n = 152; goiter prevalence in both groups >95%). However, their T-4 and TSH levels were within the normal range. After 4 mo, there was a significant treatment effect on urinary iodine levels (P < 0.0001), but the levels of the treated group were still below normal (median = 7.9 <mu>mol/L). No significant differences were found in T-4 and TSH levels, weight gain, cognitive or motor function. The findings suggest that Lipiodol supplementation in moderately iodine-deficient children with normal T-4 levels is unlikely to benefit their cognitive function. However, it remains possible that other iodine preparations may have benefits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:16:30