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Titolo:
Modeling of evoked field potentials in hippocampal CA1 area describes their dependence on NMDA and GABA receptors
Autore:
Sargsyan, AR; Papatheodoropoulos, C; Kostopoulos, GK;
Indirizzi:
Univ Patras, Sch Med, Dept Physiol, Patras 26500, Greece Univ Patras Patras Greece 26500 Med, Dept Physiol, Patras 26500, Greece Natl Acad Sci Armenia, Orbeli Inst Physiol, Yerevan 375028, Armenia Natl Acad Sci Armenia Yerevan Armenia 375028 ol, Yerevan 375028, Armenia
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 2, volume: 104, anno: 2001,
pagine: 143 - 153
SICI:
0165-0270(20010115)104:2<143:MOEFPI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED-PULSE FACILITATION; RAT HIPPOCAMPUS; PYRAMIDAL NEURONS; DENDRITIC INHIBITION; RECURRENT INHIBITION; COMPUTER-SIMULATION; THETA-RHYTHM; REGION; CELLS; GENERATION;
Keywords:
simulation; field potentials; hippocampus; inhibition; paired-pulse; NMDA; GABA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Kostopoulos, GK Univ Patras, Sch Med, Dept Physiol, Patras 26500, Greece Univ Patras Patras Greece 26500 ol, Patras 26500, Greece
Citazione:
A.R. Sargsyan et al., "Modeling of evoked field potentials in hippocampal CA1 area describes their dependence on NMDA and GABA receptors", J NEUROSC M, 104(2), 2001, pp. 143-153

Abstract

A computer model of the hippocampal CA1 area, which receives synaptic inputs from CA3 neurons via the Schaffer collaterals, was constructed. Pyramidal cells (PC) and two types of interneurons were represented by compartmental models, and mechanisms of feed-forward inhibition (FFI) and recurrent inhibition were incorporated. Four types of receptor mediated synaptic conductances were used in the model: those of AMPA, GABA(A), GABA(B) and N-methyl-D-aspartate (NMDA). The output of the model, i.e. the field potential calculated at various points in space, was able to qualitatively reproduce the main features of field potentials, which were recorded in hippocampal slicesmaintained in vitro for both subthreshold and suprathreshold stimulation. In both the experiments and the model, the influence of NMDA and GABA synaptic currents affected mostly the late, decaying phase of evoked field potentials. The modeled interaction of NMDA and GABA components could explain the enhancement of the field potential late phase. which was observed experimentally during paired-pulse stimulation. (C) 2001 Elsevier Science B.V. Allrights reserved.

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Documento generato il 04/06/20 alle ore 01:20:41