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Titolo:
Effects of antisense to the alpha 2A-Adrenoceptors administered into the region of the locus ceruleus on behaviors in plus-maze and sexual behavior tests in sham-operated and castrated male rats
Autore:
Shishkina, GT; Kalinina, TS; Sournina, NY; Dygalo, NN;
Indirizzi:
Russian Acad Sci, Inst Cytol & Genet, Novosibirsk 630090, Russia Russian Acad Sci Novosibirsk Russia 630090 t, Novosibirsk 630090, Russia
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 21, anno: 2001,
pagine: 726 - 731
SICI:
0270-6474(20010115)21:2<726:EOATTA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL NORADRENALINE RELEASE; RECEPTOR MESSENGER-RNA; BINDING-SITES; ALPHA(2A)-ADRENERGIC RECEPTORS; NORADRENERGIC MECHANISMS; TESTOSTERONE TREATMENT; ALPHA-ADRENOCEPTORS; GENE-TRANSCRIPTION; GLIOMA-CELLS; YOHIMBINE;
Keywords:
alpha 2A-adrenoceptors; locus ceruleus; anxiety; male sexual behavior; antisense oligodeoxynucleotide; mRNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Dygalo, NN Russian Acad Sci, Inst Cytol & Genet, Novosibirsk 630090, Russia Russian Acad Sci Novosibirsk Russia 630090 rsk 630090, Russia
Citazione:
G.T. Shishkina et al., "Effects of antisense to the alpha 2A-Adrenoceptors administered into the region of the locus ceruleus on behaviors in plus-maze and sexual behavior tests in sham-operated and castrated male rats", J NEUROSC, 21(2), 2001, pp. 726-731

Abstract

Clinical and experimental findings have implicated brain alpha (2)-adrenoceptors in the regulation of many physiological functions, including sexual activity and stress-related behavior. However, which subtypes of the three alpha (2)-adrenoceptors that have now been cloned (alpha 2A, alpha 2B, and alpha 2C) are involved in these controls have yet to be established. Here, we investigated the contribution of alpha 2A-adrenoceptors of the locus ceruleus, the principal source of brain noradrenaline, to exploratory and sexual behaviors. Using administration of antisense oligodeoxynucleotide to inhibit the receptor expression, we found that reductions in brainstem alpha 2A-adrenoceptor mRNA levels and alpha2-adrenoceptor densities induced by antisense treatment were not accompanied by any changes in the major characteristics of male sexual activity, such as mount latencies and numbers of mounts. However, in sexual behavior tests, antisense-treated male rats had decreased numbers of rearings and thus have higher percentages of behaviors positively correlated with sexual activity. Besides, antisense-treated animalshad decreased anxiety in plus-maze tests. The data demonstrate that inhibition of alpha 2A-adrenoceptor expression in the region of the locus ceruleus has an anxiolytic-like effect and facilitates male's attention to female in sexual behavior test.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:00:12