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Titolo:
Cerebellar projections to the prefrontal cortex of the primate
Autore:
Middleton, FA; Strick, PL;
Indirizzi:
Univ Pittsburgh, Dept Neurobiol, Sch Med, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Sch Med, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Sch Med, Pittsburgh, PA 15261 USA Dept Vet Affairs Med Ctr, Pittsburgh, PA 15240 USA Dept Vet Affairs Med Ctr Pittsburgh PA USA 15240 Pittsburgh, PA 15240 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 21, anno: 2001,
pagine: 700 - 712
SICI:
0270-6474(20010115)21:2<700:CPTTPC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; HERPES-SIMPLEX VIRUS; RHESUS-MONKEY; BASAL GANGLIA; HORSERADISH-PEROXIDASE; TRANSNEURONAL TRANSPORT; THALAMIC PROJECTIONS; MACAQUE MONKEY; FRONTAL-CORTEX; MOTOR CORTEX;
Keywords:
prefrontal cortex; cerebellum; thalamus; dentate nucleus; transneuronal transport; herpes simplex virus; primate;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Strick, PL Univ Pittsburgh, Dept Neurobiol, Sch Med, W1640 Biomed Sci Tower,200 Lothrop St, Pittsburgh, PA 15261 USA Univ Pittsburgh W1640 Biomed SciTower,200 Lothrop St Pittsburgh PA USA 15261
Citazione:
F.A. Middleton e P.L. Strick, "Cerebellar projections to the prefrontal cortex of the primate", J NEUROSC, 21(2), 2001, pp. 700-712

Abstract

The cerebellum is known to project via the thalamus to multiple motor areas of the cerebral cortex. In this study, we examined the extent and anatomical organization of cerebellar input to multiple regions of prefrontal cortex. We first used conventional retrograde tracers to map the origin of thalamic projections to five prefrontal regions: medial area 9 (9m), lateral area 9 (9l), dorsal area 46 (46d), ventral area 46, and lateral area 12. Onlyareas 46d, 9m, and 9l received substantial input from thalamic regions included within the zone of termination of cerebellar efferents. This suggested that these cortical areas were the target of cerebellar output. We testedthis possibility using retrograde transneuronal transport of the McIntyre-B strain of herpes simplex virus type 1 from areas of prefrontal cortex. Neurons labeled by retrograde transneuronal transport of virus were found in the dentate nucleus only after injections into areas 46d, 9m, and 9l. The precise location of labeled neurons in the dentate varied with the prefrontal area injected. In addition, the dentate neurons labeled after virus injections into prefrontal areas were located in regions spatially separate fromthose labeled after virus injections into motor areas of the cerebral cortex. Our observations indicate that the cerebellum influences several areas of prefrontal cortex via the thalamus. Furthermore, separate output channels exist in the dentate to influence motor and cognitive operations. These results provide an anatomical substrate for the cerebellum to be involved incognitive functions such as planning, working memory, and rule-based learning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:15:01