Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release
Autore:
Okada, M; Nutt, DJ; Murakami, T; Zhu, G; Kamata, A; Kawata, Y; Kaneko, S;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 rosaki, Aomori 0368216, Japan Univ Bristol, Psychopharmacol Unit, Bristol BS8 1TD, Avon, England Univ Bristol Bristol Avon England BS8 1TD Bristol BS8 1TD, Avon, England
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 21, anno: 2001,
pagine: 628 - 640
SICI:
0270-6474(20010115)21:2<628:ARSMTM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; IN-VIVO MICRODIALYSIS; CALCIUM-CHANNEL TYPES; N-TYPE; CA2+ CHANNELS; SYNAPTIC TRANSMISSION; TRANSMITTER RELEASE; ADENYLATE-CYCLASE; STRIATAL DOPAMINE; TETANUS TOXIN;
Keywords:
adenosine; serotonin; microdialysis; voltage-sensitive Ca2+ channel; protein kinase; SNARE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Okada, M Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368216, Japan Hirosaki Univ Hirosaki Aomori Japan 0368216 omori 0368216, Japan
Citazione:
M. Okada et al., "Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release", J NEUROSC, 21(2), 2001, pp. 628-640

Abstract

To clarify the mechanisms of interaction between adenosine A(1) receptor (A1-R) and adenosine A(2) receptor (A2-R) on neurotransmitter release, this study determined the functional interactions among adenosine receptors (AD-Rs), voltage-sensitive Ca2+ channels (VSCCs), protein kinases (PKs), and synaptic proteins [N-ethylmaleimide-sensitive factor (NSF) attachment protein(SNAP) receptors] on hippocampal serotonin release using in vivo microdialysis in freely moving rat. Basal serotonin release was regulated by two functional complexes: N-type VSCC (N-VSCC)/calcium-phospholipid-dependent protein kinase (PKC)/syntaxin (major pathway) and P-type VSCC (PVSCC)/cyclic AMP-dependent protein kinase (PKA)/synaptobrevin (minor pathway). However, K+-evoked serotonin release was regulated by N-VSCC/PKC/syntaxin (minor pathway) and P-VSCC/PKA/synaptobrevin (major pathway). A1-R antagonists increased basal serotonin release, which was reduced by inhibitors of N-VSCC, PKC, and syntaxin predominantly and by inhibitors of PKA and synaptobrevin weakly, but was not affected by P-VSCC inhibitor. In the presence of A1-R antagonist, A2-R agonists increased basal serotonin release, which was inhibited by inhibitors of P-VSCC, PKA, and synaptobrevin predominantly and reduced by inhibitors of N-VSCC, PKC, and syntaxin weakly. Under the condition of activation of adenylate cyclase in the absence of A1-R antagonists, A2-R agonists increased basal serotonin release. A1-R antagonist and A2-R agonist enhanced K+-evoked serotonin release, which was inhibited by inhibitors of P-VSCC, PKA, and synaptobrevin predominantly. These results suggest that an activation of A1-R suppresses serotonin release via inhibition of both N-VSCC/PKC/syntaxin and P-VSCC/PKA/synaptobrevin pathways, and an activation of A2-R stimulates serotonin release via enhancement of the P-VSCC/PKA/synaptobrevin pathway. Therefore, PKA activity plays an important role in the interaction between A1-R and A2-R on hippocampal serotonin release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:30:09