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Titolo:
Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line
Autore:
Benatar, M; Blaes, F; Johnston, I; Wilson, K; Vincent, A; Beeson, D; Lang, B;
Indirizzi:
John Radcliffe Hosp, Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England John Radcliffe Hosp Oxford England OX3 9DS Grp, Oxford OX3 9DS, England Groote Schuur Hosp, Dept Neurol, ZA-7925 Cape Town, South Africa Groote Schuur Hosp Cape Town South Africa ZA-7925 ape Town, South Africa Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02215 USA Beth Israel Deaconess Med Ctr Boston MA USA 02215 l, Boston, MA 02215 USA Univ Giessen, Dept Neurol, D-35392 Giessen, Germany Univ Giessen GiessenGermany D-35392 pt Neurol, D-35392 Giessen, Germany
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1, volume: 113, anno: 2001,
pagine: 153 - 162
SICI:
0165-5728(20010201)113:1<153:PNAEBA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EATON-MYASTHENIC-SYNDROME; CALCIUM-CHANNEL AUTOANTIBODIES; P-TYPE; RECEPTOR ANTIBODY; ACTION-POTENTIALS; CANCER CELLS; CURRENTS; PROTEIN; RELEASE; SERUM;
Keywords:
paraneoplastic neurological disorders; small cell lung carcinoma; autoantibodies; voltage-gated calcium channels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Lang, B John Radcliffe Hosp, Inst Mol Med, Neurosci Grp, Oxford OX3 9DS, England John Radcliffe Hosp Oxford England OX3 9DS ford OX3 9DS, England
Citazione:
M. Benatar et al., "Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line", J NEUROIMM, 113(1), 2001, pp. 153-162

Abstract

Small cell lung carcinoma (SCLC) is a tumour of neuroendocrine origin often found in association with autoimmune paraneoplastic neurological disorders. We established a SCLC cell line from a woman with Lambert-Eaton myasthenic syndrome (LEMS) who developed antibodies to both the P/Q-type voltage-gated calcium channels (VGCC) and the muscle acetycholine receptor (AChR). Weused a range of techniques to establish which neuronal antigens were expressed in her tumour cell line. The results show that many proteins involved in exocytosis are present in the SCLC cells, and that depolarisation-dependent release of [H-3]-serotonin is linked to calcium influx through P/Q-typeVGCCs. In addition, some of the subunits encoding the AChR and both agrin and ARIA, molecules released from the motor nerve during development, were expressed. These results suggest that many potential antigenic targets are present in SCLC, and indicate a surprising 'motor nerve terminal'-like characteristic of this line. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:53:59