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Titolo:
A novel monoclonal antibody specific for the N-terminal end of GAD65
Autore:
Hampe, CS; Lundgren, P; Daniels, TL; Hammerle, LP; Marcovina, SM; Lernmark, A;
Indirizzi:
Univ Washington, Robert H Williams Lab, Dept Med, Seattle, WA 98105 USA Univ Washington Seattle WA USA 98105 Lab, Dept Med, Seattle, WA 98105 USA Univ Washington, NW Lipid Res Labs, Dept Med, Seattle, WA 98103 USA Univ Washington Seattle WA USA 98103 abs, Dept Med, Seattle, WA 98103 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1, volume: 113, anno: 2001,
pagine: 63 - 71
SICI:
0165-5728(20010201)113:1<63:ANMASF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; DEPENDENT DIABETES-MELLITUS; GAMMA-AMINOBUTYRIC-ACID; STIFF-MAN SYNDROME; DIAGNOSTIC SENSITIVITY; DIFFERENT EPITOPES; PANCREATIC-ISLETS; CHILDHOOD IDDM; MICE DEFICIENT; 65-KDA ISOFORM;
Keywords:
GAD67; type 1 diabetes; autoimmunity; polymerase chain reaction; immunoglobulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Hampe, CS Univ Washington, Robert H Williams Lab, Dept Med, Box 357710, Seattle, WA 98105 USA Univ Washington Box 357710 Seattle WA USA 98105 le, WA 98105 USA
Citazione:
C.S. Hampe et al., "A novel monoclonal antibody specific for the N-terminal end of GAD65", J NEUROIMM, 113(1), 2001, pp. 63-71

Abstract

We describe a novel monoclonal antibody raised towards the N-terminus of the 65 kDa isoform of glutamate decarboxylase (GAD65). This N-GAD65 mAb is highly specific for GAD65 and can be used in a wide range of applications such as Western blot analysis. immunoprecipitation and immunocytochemistry. Full-length cDNAs coding for N-GAD65 mAb heavy and light chains were cloned and characterized by nucleotide sequence analysis. Both heavy and light chain-specific cDNAs are functional and are members of mouse heavy chain subgroup IgG1 and kappa chain group 2, respectively. Comparing the N-GAD65 mAb gene sequences with GenBank shows that the cDNAs were not reported previously. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:05:27