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Titolo:
Non-steroidal anti-inflammatory drugs with different cyclooxygenase inhibitory profiles that prevent aberrant crypt foci formation but vary in acute gastrotoxicity in a rat model
Autore:
Brown, WA; Skinner, SA; Malcontenti-Wilson, C; Misajon, A; DeJong, T; Vogiagis, D; OBrien, PE;
Indirizzi:
Monash Univ, Alfred Hosp, Dept Surg, Melbourne, Vic 3181, Australia MonashUniv Melbourne Vic Australia 3181 , Melbourne, Vic 3181, Australia
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
fascicolo: 12, volume: 15, anno: 2000,
pagine: 1386 - 1392
SICI:
0815-9319(200012)15:12<1386:NADWDC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; FAMILIAL ADENOMATOUS POLYPOSIS; PROSTAGLANDIN G/H SYNTHASE-1; COLON CARCINOGENESIS; SELECTIVE-INHIBITION; COLORECTAL-CANCER; SULINDAC; EXPRESSION; TUMORS; GROWTH;
Keywords:
aberrant crypts; chemoprevention; colorectal cancer; gastrotoxicity; non-steroidal anti-inflammatory drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, WA Monash Univ, Alfred Hosp, Dept Surg, Commercial Rd, Prahran, Vic3181, Australia Monash Univ Commercial Rd Prahran Vic Australia 3181 , Australia
Citazione:
W.A. Brown et al., "Non-steroidal anti-inflammatory drugs with different cyclooxygenase inhibitory profiles that prevent aberrant crypt foci formation but vary in acute gastrotoxicity in a rat model", J GASTR HEP, 15(12), 2000, pp. 1386-1392

Abstract

Background: Standard non-steroidal anti-inflammatory drugs (NSAIDs) reducethe risk of colorectal cancer; however, their use as preventive agents is limited by their inherent toxicity. Drugs that selectively inhibit cyclooxygenase-2 (COX-2) may be useful in this setting as they are supposedly less toxic. No study has directly compared the ability of standard NSAIDs and selective COX-2 inhibitors to inhibit colorectal cancer at clinically relevant doses. Methods: Aberrant crypt foci (ACF) were induced in Sprague-Dawley rats by using 1,2-dimethylhydrazine (DMH). Test agents or vehicle were then administered for 3 weeks, twice daily through orogastric gavage. At the end of this period, the number and multiplicity of ACF were determined. The agents tested at equivalent anti-inflammatory doses were: sulindac and indomethacin (standard NSAIDs), meloxicam (selective COX-2 inhibitor), celecoxib (specific COX-2 inhibitor) and sulindac sulfone (no known COX activity). Acute gastrotoxicity of NSAID in rats was compared by using quantitative histology. Results: All test agents reduced the number of ACE There was a 42% reduction with indomethacin, 46% with sulindac, 46% with meloxicam, 22% with celecoxib and 36% with sulindac sulfone. Only the COX-2 inhibitors caused no significant gastrotoxicity in rats. Conclusions: Cyclooxygenase-2 inhibitors are potentially ideal chemopreventive agents as they inhibit ACF and are not gastrotoxic. (C) 2000 BlackwellScience Asia Pty Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:06:38