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Titolo:
Novel proteoglycan epitope expressed in functionally discrete patterns in primate cortical and subcortical regions
Autore:
Pimenta, AF; Strick, PL; Levitt, P;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Neurobiol, Ctr Neural Basis Cognit, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Cognit, Pittsburgh, PA 15261 USA Vet Adm Med Ctr, Res Serv, Pittsburgh, PA 15261 USA Vet Adm Med Ctr Pittsburgh PA USA 15261 es Serv, Pittsburgh, PA 15261 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 3, volume: 430, anno: 2001,
pagine: 369 - 388
SICI:
0021-9967(20010212)430:3<369:NPEEIF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN SULFATE PROTEOGLYCAN; CENTRAL-NERVOUS-SYSTEM; MEMBRANE-PROTEIN LAMP; CAT VISUAL-CORTEX; PRE-MESSENGER-RNA; LATERAL GENICULATE-NUCLEUS; MAMMALIAN CENTRAL NEURONS; MONOCLONAL-ANTIBODIES; LIMBIC SYSTEM; ADHESION MOLECULES;
Keywords:
interstitial neurons; stellate neurons; cell surface antigens; monoclonal antibodies;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Levitt, P Univ Pittsburgh, Sch Med, Dept Neurobiol, Ctr Neural Basis Cognit, E1440 BST, Pittsburgh, PA 15261 USA Univ Pittsburgh E1440 BST PittsburghPA USA 15261 , PA 15261 USA
Citazione:
A.F. Pimenta et al., "Novel proteoglycan epitope expressed in functionally discrete patterns in primate cortical and subcortical regions", J COMP NEUR, 430(3), 2001, pp. 369-388

Abstract

The molecular diversity of neuronal subpopulations was examined with a newmonoclonal antibody, 8B3, that recognizes a condroitin sulfate proteoglycan expressed in anatomically discrete domains of central nervous system regions. In the neocortex, interneurons display 8B3 immunoreactivity in a rostrocaudal gradient, with a distinctive staining pattern that distinguishes known cytoarchitectonic and functional boundaries. The distribution pattern of 8B3 immunoreactivity in subcortical structures is very restricted. In thestriatum, 8B3 stains spiny stellate neurons clearly defining a compartmentthat may correspond to the matrix. Gradients of immunoreactivity are detected in the putamen, globus pallidus, and deep cerebellar nuclei, where the most dense areas of 8B3 immunoreactivity corresponds to zones of polysynaptic projections to association prefrontal cortex. In contrast, the sensorimotor domains express lower levels of immunoreactivity. Only the projection neurons of the ventrolateral nucleus and the GABAergic neurons of the reticular nucleus express significant 8B3 immunoreactivity in the thalamus. In the spinal cord, 8B3 immunoreactivity is primarily associated with a subpopulation of motor neurons in the ventral horn and neurons in Clarke's nucleus. The complex distribution pattern reflects novel aspects of the functional organization of cortical and subcortical systems in the CNS of the primate brain and represents a potentially useful tool to assess subpopulations of neurons and brain areas as putative targets in human disease. J. Comp. Neurol. 430:369-388, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:30:50