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Titolo:
Prognostic factors in localized primary synovial sarcoma: A multicenter study of 128 adult patients
Autore:
Trassard, M; Le Doussal, V; Hacene, K; Terrier, P; Ranchere, D; Guillou, L; Fiche, M; Collin, F; Vilain, MO; Bertrand, G; Jacquemier, J; Sastre-Garau, X; Bui, NB; Bonichon, F; Coindre, JM;
Indirizzi:
French Federat Canc Ctr Sarcoma Grp, Paris, France French Federat Canc CtrSarcoma Grp Paris France oma Grp, Paris, France
Titolo Testata:
JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 2, volume: 19, anno: 2001,
pagine: 525 - 534
SICI:
0732-183X(20010115)19:2<525:PFILPS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOFT-TISSUE SARCOMAS; MALIGNANT FIBROUS HISTIOCYTOMA; MULTIVARIATE-ANALYSIS; FEATURES; SURVIVAL; CANCER; SERIES; TUMORS; KI-67; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Trassard, M Ctr Rene Huguenin, Lab Anat & Cytol Pathol, 35 Rue Dailly, F-92210 St Cloud, France Ctr Rene Huguenin 35 Rue Dailly St Cloud France F-92210 rance
Citazione:
M. Trassard et al., "Prognostic factors in localized primary synovial sarcoma: A multicenter study of 128 adult patients", J CL ONCOL, 19(2), 2001, pp. 525-534

Abstract

Purpose: To identify most significant and therapeutically relevant prognostic factors in adults with localized primary synovial sarcomas (SS) and to confirm the usefulness of the French Federation of Cancer Centers (FNCLCC) grading system, the prognostic impact of which has been already proven in soft tissue sarcomas,Patients and Methods: Data on 128 patients with nonmetastatic SS collectedfrom ct cooperative database by the FNCLCC Sarcoma Group between 1980 and 1994 were studied retrospectively. Immunohistochemistry was performed at diagnosis in 77 cases (61%). The tumors were classified as biphasic (n = 45),monophasic fibrous (n = 72), and poorly differentiated (n = 10) subtypes. Histologic grade was determined according to the FNCLCC method, and vascular invasion was assessed in every case. Results: The 5-year disease-specific survival (DSS) rate for this series of patients with localized SS was 62.9% (+/- 9.6% [SD]) with a median follow-up time of 37 months (range, 8 to 141 months), In multivariate analysis, the adverse risk factors associated with decreased DSS were International Union Against Cancer/ American Joint Committee on Cancer stage III/IVA disease, male sex, and truncal tumor locations. For metastasis-free survival (MFS), disease stage III/IVA, tumor necrosis, and monophasic subtypes were the major factors associated with a less favorable prognosis. Separately, when not using disease stage, tumor necrosis, and mitotic activity, histologic grade became the most significant prognostic factor for both DSS and MFS. Inaddition, larger tumors and older patients become associated with a significantly worse prognosis. Independent adverse risk factors for local recurrence-free survival included histologic grade 3 and truncal tumor location. Conclusion: These data confirm that not all SS present the same severe outcome. High-risk patients identified on the basis of these parameters may qualify for an aggressive treatment approach. J Clin Oncol 19:525-534. (C) 2001 by American Society of Clinical Oncology.

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Documento generato il 23/09/20 alle ore 05:21:41