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Titolo:
Ubiquitous expression of the calcitonin-I gene in multiple tissues in response to sepsis
Autore:
Muller, B; White, JC; Nylen, ES; Snider, RH; Becker, KL; Habener, JF;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Howard Hughes Med Inst,Lab Mol Endocrinol, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 Lab Mol Endocrinol, Boston, MA 02114 USA Vet Affairs Med Ctr, Washington, DC 20422 USA Vet Affairs Med Ctr Washington DC USA 20422 Ctr, Washington, DC 20422 USA George Washington Univ, Dept Surg & Med, Washington, DC 20422 USA George Washington Univ Washington DC USA 20422 , Washington, DC 20422 USA
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 86, anno: 2001,
pagine: 396 - 404
SICI:
0021-972X(200101)86:1<396:UEOTCG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-GOLGI NETWORK; PROCALCITONIN CONCENTRATIONS; ENDOPROTEOLYTIC CLEAVAGE; SYSTEMIC INFLAMMATION; SERUM PROCALCITONIN; PERMEABILIZED CELLS; RNA; PROSOMATOSTATIN; INHIBITION; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, B Univ Basel Hosp, Dept Internal Med, Div Endocrinol Diabetol & Clin Nutr, Petersgraben 4, CH-4031 Basel, Switzerland Univ Basel Hosp Petersgraben 4 Basel Switzerland CH-4031 erland
Citazione:
B. Muller et al., "Ubiquitous expression of the calcitonin-I gene in multiple tissues in response to sepsis", J CLIN END, 86(1), 2001, pp. 396-404

Abstract

Calcitonin precursors (CTpr), including procalcitonin, are important markers and also potentially harmful mediators in response to microbial infections. The source and function of CTpr production in sepsis, however, remains an enigma. In the classical view, the transcription of the CT-I gene is restricted to neuroendocrine cells, in particular the C cells of the thyroid. To better understand the pathophysiology of CTpr induction in sepsis, we used an animal model analog to human sepsis, in which bacterial infection is induced in hamsters by implanting Escherichia coli pellets ip. Compared with control hamsters, levels of CTpr mere elevated several fold in septic plasma and in nearly all septic hamster tissues analyzed. Unexpectedly, CT-messenger RNA was ubiquitously and uniformly expressed in multiple tissues throughout the body in response to sepsis. Notably, the transcriptional expression of CT-messenger RNA seemed more widely up-regulated in sepsis than were classical cytokines (e.g. tumor necrosis factor-alpha and interleukin-6). Our findings, which describe a potentially new mechanism of host response to a microbial infection mediated by CTpr, introduce a new pathophysiological role for the CT-I gene.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:50:55