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Titolo:
Apoprotein C-III and E-containing lipoparticles are markedly increased in HIV-infected patients treated with protease inhibitors: Association with the development of lipodystrophy
Autore:
Bonnet, E; Ruidavets, JB; Tuech, J; Ferrieres, J; Collet, X; Fauvel, J; Massip, P; Perret, B;
Indirizzi:
Toulouse Univ Hosp, INSERM, U518, F-31059 Toulouse, France Toulouse Univ Hosp Toulouse France F-31059 518, F-31059 Toulouse, France Toulouse Univ Hosp, Serv Malad Infect, F-31059 Toulouse, France Toulouse Univ Hosp Toulouse France F-31059 ect, F-31059 Toulouse, France Toulouse Univ Hosp, INSERM, U326, F-31059 Toulouse, France Toulouse Univ Hosp Toulouse France F-31059 326, F-31059 Toulouse, France Toulouse Univ Hosp, Lab Biochim 3, F-31059 Toulouse, France Toulouse Univ Hosp Toulouse France F-31059 m 3, F-31059 Toulouse, France
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 86, anno: 2001,
pagine: 296 - 302
SICI:
0021-972X(200101)86:1<296:ACAELA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E; LOW-DENSITY; MYOCARDIAL-INFARCTION; TRIGLYCERIDE-RICH; LDL RECEPTOR; APO-CIII; LIPOPROTEINS; BINDING; HYPERTRIGLYCERIDEMIA; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Perret, B Hop Purpan, INSERM, U326, F-31059 Toulouse, France Hop Purpan Toulouse France F-31059 6, F-31059 Toulouse, France
Citazione:
E. Bonnet et al., "Apoprotein C-III and E-containing lipoparticles are markedly increased in HIV-infected patients treated with protease inhibitors: Association with the development of lipodystrophy", J CLIN END, 86(1), 2001, pp. 296-302

Abstract

Long-term therapy with protease inhibitors (PIs) can induce hypertriglyceridemia and development of a lipodystrophy. To better understand these metabolic alterations, the apoprotein and lipoparticle profile was investigated in male HIV patients under antiretroviral therapy: 49 received PIs, and 14 were given only two reverse transcriptase inhibitors. As controls, 63 male subjects were selected from a population study carried out in the Toulouse,France, area. Fasting glucose, insulin, and C-peptide were also determined. All patients under PIs displayed low levels of plasma glucose and increased insulin. PI administration was associated with moderate hypertriglyceridemia, low high-density cholesterol and apolipoprotein (apo) A-I levels. Themost striking changes were a 2- to 3-fold increase in apo E and apo C-III,essentially recovered as associated to apo B-containing lipoparticles. Levels of those lipoparticles were two to eight times above control values. About 50% of PI-treated patients had developed a patent lipodystrophy. Multivariate analysis revealed that, among the investigated parameters, apo C-IIIwas the only one found strongly associated with the occurrence of lipodystrophy (odds ratio, 5.5; P < 0.015). Finally, 13 PI-receiving subjects with patent hypertriglyceridemia were given fenofibrate and were reevaluated 2 months later. Triglycerides, apo E, apo C-III, and the corresponding lipoparticles had returned to nearly normal levels. These results document the accumulation of potentially atherogenic lipoparticles under PIs. Apo C-III mayplay a pivotal role in the development of hypertriglyceridemia and lipodystrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:45:16