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Titolo:
Intrauterine programming of adult body composition
Autore:
Gale, CR; Martyn, CN; Kellingray, S; Eastell, R; Cooper, C;
Indirizzi:
Univ Southampton, Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD 6 6YD, Hants, England No Gen Hosp, Osteoporosis Ctr, Sheffield S5 7AU, S Yorkshire, England No Gen Hosp Sheffield S Yorkshire England S5 7AU AU, S Yorkshire, England
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 86, anno: 2001,
pagine: 267 - 272
SICI:
0021-972X(200101)86:1<267:IPOABC>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; X-RAY ABSORPTIOMETRY; SOFT-TISSUE COMPOSITION; CHILDHOOD GROWTH; BIRTH-WEIGHT; FETAL GROWTH; ELDERLY MEN; MASS; WOMEN; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Cooper, C Univ Southampton, Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD ts, England
Citazione:
C.R. Gale et al., "Intrauterine programming of adult body composition", J CLIN END, 86(1), 2001, pp. 267-272

Abstract

Epidemiological studies suggest an association between weight in infancy and the risk of osteoporosis in later life. The extent to which this reflects environmental influences on skeletal growth and metabolism before birth or during the first year of postnatal life remains uncertain. We therefore examined the association between birth weight and adult body composition (bone, lean, and fat mass) in a cohort of 143 men and women, aged 70-75 yr, who were born in Sheffield, UK, and still lived there. The subjects underwentassessment of body composition by dual energy x-ray absorptiometry. Neonatal anthropometric information included birth weight, birth length, head size, and abdominal circumference. There were significant (P < 0.01) positive associations between birth weight and adult, whole body, bone, and lean mass among men and women. These were mirrored in significant (P < 0.03) associations between birth weight and bone mineral content at the lumbar spine and femoral neck. Associations between birth weight and whole body fat were weaker and not statistically significant. The associations of birth weight with whole body bone mineral and lean mass remained statistically significant after adjustment for age, sex, and adult height. They also remained significant after adjustment for cigarette smoking, alcohol consumption, dietarycalcium intake, and physical inactivity. These data are in accord with previous observations that anthropometric measures in infancy are associated with skeletal size in adulthood. The presence of these relationships at birth adds to the evidence that bone and muscle growth may be programmed by genetic and/or environmental influences during intrauterine life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 00:52:45