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Titolo:
Bioavailable estradiol may be an important determinant of osteoporosis in men: The MINOS study
Autore:
Szulc, P; Munoz, F; Claustrat, B; Garnero, P; Marchand, F; Duboeuf, F; Delmas, PD;
Indirizzi:
INSERM, U403, F-69437 Lyon, France INSERM Lyon France F-69437INSERM, U403, F-69437 Lyon, France Hop Neurocardiol, F-69437 Lyon, France Hop Neurocardiol Lyon France F-69437 Neurocardiol, F-69437 Lyon, France Soc Secours Miniere Bourgogne, F-71300 Montceau Mines, France Soc Secours Miniere Bourgogne Montceau Mines France F-71300 ines, France
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 86, anno: 2001,
pagine: 192 - 199
SICI:
0021-972X(200101)86:1<192:BEMBAI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; ESTROGEN-RECEPTOR GENE; ONE-STEP ELISA; AROMATASE DEFICIENCY; DEGRADATION PRODUCTS; SEX-HORMONES; ELDERLY MEN; I COLLAGEN; POSTMENOPAUSAL WOMEN; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Delmas, PD Hop Edouard Herriot, INSERM, U403, Pl Arsonval, F-69437 Lyon, France Hop Edouard Herriot Pl Arsonval Lyon France F-69437 on, France
Citazione:
P. Szulc et al., "Bioavailable estradiol may be an important determinant of osteoporosis in men: The MINOS study", J CLIN END, 86(1), 2001, pp. 192-199

Abstract

During recent years, experimental data, case reports, and epidemiological studies have suggested an important role for estradiol in bone metabolism in men. In a cohort of 596 men, aged 51-85 yr, we measured bone mineral density (BMD) of the lumbar spine, hip, total body, and forearm; serum levels of sex steroid hormones [total and free testosterone, total estradiol (17 betaE(2)), bioavailable estradiol (bio-17 betaE(2)), androstenedione, and sexhormone-binding globulin]; and markers of bone turnover [serum osteocalcin, bone alkaline phosphatase, N-terminal extension propeptide of type I collagen, and beta -isomerized C-terminal telopeptide of collagen type I (beta CTX)], as well as urinary excretion of beta CTX and deoxypyridinoline (DPyr). An age-related decrease was found for bio-17 betaE(2) (r = -0.16; P < 0.001), free testosterone (r = -0.25; P < 0.001), free testosterone index (r = -0.32; P < 0.001), and androstenedione (r = -0.22; P < 0.001), but not for total 17 betaE(2) or total testosterone. 17 betaE(2) and bio-17 betaE(2),but not other hormones, were correlated with BMD after adjustment for age and body weight. In men with a bio-17 betaE(2) level in the lowest quartile, the average BMD was lower than in men having a bio-17 betaE(2) level in the highest quartile by 6.6-8.7% according to the site of measurement, whichcorresponded to 0.45-0.65 SD. In age- and body weight-adjusted models, bio-17 betaE(2), but not other hormones, was negatively correlated with bone markers (e.g., osteocalcin: r = -0.14; P < 0.001; urinary <beta>CTX: r = -0.20; P = 0.0001; DPyr: r = -0.14; P < 0.001). In men with the lowest concentration of bio-17<beta>E-2 (first quartile), the concentrations of markers of bone turnover were higher by 11-35% (or 0.4-0.7 SD) than in men having the highest bio-17 betaE(2) level (upper quartile). In men in the lowest quartile for bio-17 betaE(2) and in the highest quartile for urinary DPyr or beta CTX, the BMD of total hip and that of distal forearm were 8% and 10% lower than in men in the highest quartile for bio-17 betaE(2) and in the lowest quartile for DPyr or beta CTX. In the age- and body weight-adjusted multiple regression models, bio-17 betaE(2) contributed significantly to the explanation for the variability in all markers. In summary, we found in a cross-sectional analysis of a cohort of men thatlow levels of bio-17 betaE(2) are associated with high bone turnover and low BMD. These data suggest that the age-related decrease in bio-17 betaE(2)contributes to bone loss in elderly men by increasing bone turnover. Low 17 betaE(2) levels may be an important risk factor for osteoporosis in men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:29:06