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Titolo:
Verapamil prevents stretch-induced shortening of atrial effective refractory period in Langendorff-perfused rabbit heart
Autore:
Zarse, M; Stellbrink, C; Athanatou, E; Robert, J; Schotten, U; Hanrath, P;
Indirizzi:
Rhein Westfal TH Aachen, Dept Internal Med & Cardiol, Aachen, Germany Rhein Westfal TH Aachen Aachen Germany l Med & Cardiol, Aachen, Germany
Titolo Testata:
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
fascicolo: 1, volume: 12, anno: 2001,
pagine: 85 - 92
SICI:
1045-3873(200101)12:1<85:VPSSOA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CALCIUM TRANSIENTS; PIG VENTRICULAR MYOCYTES; FIBRILLATION; HUMANS; TACHYCARDIA; PRESSURE; MECHANISMS; VULNERABILITY; ARRHYTHMIAS; ACTIVATION;
Keywords:
rapid pacing; atrial dilation; atrial fibrillation; calcium overload; ischemia; acidosis; verapamil; glibenclamide; cariporide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Zarse, M Univ Technol Aachen, Med Clin 1, Pauwelsstr 30, D-52074 Aachen, Germany Univ Technol Aachen Pauwelsstr 30 Aachen Germany D-52074 Germany
Citazione:
M. Zarse et al., "Verapamil prevents stretch-induced shortening of atrial effective refractory period in Langendorff-perfused rabbit heart", J CARD ELEC, 12(1), 2001, pp. 85-92

Abstract

Verapamil Prevents Stretch-Induced AERP Shortening. Introduction: Atrial dilation and rapid pacing reduce atrial effective refractory periods (AERPs), thereby increasing the susceptibility to sustained atrial fibrillation (AF) in Langendorff-perfused rabbit hearts. It is unclear whether similar pathophysiologic mechanisms are operative in short-term electrophysiologic changes caused by dilation and rapid pacing. Therefore, we analyzed whether both forms of short-term electrophysiologic changes are similarly affected bypharmacologic interventions acting on different potential mechanisms underlying these changes. Methods and Results: Thirty Langendorff-perfuse rabbit hearts underwent a protocol with stepwise increase of intra-atrial pressure from 0 to 12 cmH(2)O followed by 10 minutes of rapid pacing at 4 cmN(2)O. The protocol was repeated after addition of glibenclamide (10 mu mol/L, n = 7),cariporide (1 mu mol/L, n = 7), or verapamil (1 mu mol/L, n = 9). In the basal state, increase of intra-atrial pressure from 0 to 12 cmH(2)O decreased AERPs from 85 /- 11 to 55 +/- 9 msec (P < 0.01), rapid pacing at low intra-atrial pressure (4 cmH(2)O) decreased AERP to a similar extent, from 81 +/- 11 to 60 +/-10 (P < 0.01). At higher intra-atrial pressure, decrease of AERP was more pronounced (10 cmH(2)O: 37 +/- 2 msec) (n = 7). Addition of verapamil decreased basal AERP from 86 +/- 10 msec to 68 +/- 11 msec (P < 0.05). Short-term electrophysiologic changes due to atrial dilation were abolished; changesdue to rapid pacing were reduced but still present. Glibenclamide and cariporide had no significant effect. Conclusion: Langendorff-perfuse rabbit heart is a suitable model for studying short-term electrophysiologic changes due to both rapid pacing and atrial dilation. AERPs are shortened to a similar extent by both mechanisms, whereas a combination of the two leads to more pronounced AERP reduction. Calcium overload plays a crucial role in short-term electrophysiologic changescaused by atrial dilation, whereas atrial ischemia or acidosis has no significant impact.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:25:17