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Titolo:
Interaction of nutrition and binge ethanol treatment on brain damage and withdrawal
Autore:
Crews, FT; Braun, CJ; Ali, R; Knapp, DJ;
Indirizzi:
Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 udies, Chapel Hill, NC 27599 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL SCIENCE
fascicolo: 1, volume: 8, anno: 2001,
pagine: 134 - 142
SICI:
1021-7770(200101/02)8:1<134:IONABE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONAL DEGENERATION; OLFACTORY DEFICITS; EMERGENCY ROOM; ALCOHOL; INTOXICATION; DEPENDENCE; LEVEL; RATS;
Keywords:
ethanol, chronic; diet; withdrawal; neurodegeneration; silver stain; cortex; hippocampus; nutrition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Crews, FT Univ N Carolina, Sch Med, Bowles Ctr Alcohol Studies, CB 7178,Thurston Bowles Bldg, Chapel Hill, NC 27599 USA Univ N Carolina CB 7178,Thurston Bowles Bldg Chapel Hill NC USA 27599
Citazione:
F.T. Crews et al., "Interaction of nutrition and binge ethanol treatment on brain damage and withdrawal", J BIOMED SC, 8(1), 2001, pp. 134-142

Abstract

To determine if nutrition plays a role in ethanol withdrawal and alcohol-induced brain damage, the effects of a 4-day ethanol binge treatment using ethanol in a nutritionally complete liquid diet compared to ethanol mixed with water were studied. The nutritionally complete diet group (ETOH-diet) received a complete diet of sugars, proteins and fats with vitamins and minerals with approximately 53% of calories from ethanol while the nutritionallydeprived group (ETOH-H2O) received 100% of calories from ethanol. No difference in withdrawal behavior was found between the ETOH-diet and ETOH-H2O groups during the 72-hour period studied. In addition, no difference was seen for serum levels of magnesium and zinc taken at last dose or following 72h of withdrawal. Serum alanine aminotransferase (ALT) and ammonia were increased in both groups with ETOH-diet showing a greater increase in ALT thanETOH-H2O. Both groups showed damage in the olfactory bulb, perirhinal, agranular insular, piriform and lateral entorhinal cortical areas as well as hippocampal dentate gyrus and CA-3, Interestingly, the ETOH-diet group displayed more damage at last dose in the posterior dentate and CA-3 of hippocampus than did the ETOH-H2O group. This study suggests that nutritional components and total caloric intake do not effect behavior during ethanol withdrawal and that a nutritionally complete diet may increase ethanol-induced brain damage. Copyright (C) 2001 National Science Council, ROC and S. Karger AG, Basel.

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Documento generato il 06/04/20 alle ore 08:45:38