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Titolo:
Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-Infected patients with failure of highly active antiretroviral therapy
Autore:
Rousseau, MN; Vergne, L; Montes, B; Peeters, M; Reynes, J; Delaporte, E; Segondy, M;
Indirizzi:
CHU Montpellier, Virol Lab, Montpellier, France CHU Montpellier Montpellier France lier, Virol Lab, Montpellier, France CHU Montpellier, Dept Infect & Trop Dis, Montpellier, France CHU Montpellier Montpellier France fect & Trop Dis, Montpellier, France Inst Rech & Dev, Retrovirus Lab, Montpellier, France Inst Rech & Dev Montpellier France Retrovirus Lab, Montpellier, France
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 1, volume: 26, anno: 2001,
pagine: 36 - 43
SICI:
1525-4135(20010101)26:1<36:PORMTA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAVUDINE PLUS DIDANOSINE; REVERSE-TRANSCRIPTASE; CONFERRING RESISTANCE; MULTIDRUG-RESISTANCE; PROTEASE INHIBITORS; COMBINATION THERAPY; VIRAL LOAD; HIV-1; ZIDOVUDINE; MONOTHERAPY;
Keywords:
mutations; genotypic resistance; highly active antiretroviral therapy; treatment failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Segondy, M Hop St Eloi, Virol Lab, 80 Ave Augustin Fliche, F-34295 Montpellier 05, France Hop St Eloi 80 Ave Augustin Fliche Montpellier France 05 rance
Citazione:
M.N. Rousseau et al., "Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-Infected patients with failure of highly active antiretroviral therapy", J ACQ IMM D, 26(1), 2001, pp. 36-43

Abstract

Resistance-mutation patterns in the reverse transcriptase (RT) and protease genes of HIV-1 were analyzed in 22 patients who had been extensively pretreated and who failed to respond to highly active antiretroviral therapy (HAART). The number of mutations ranged from 8 to 19 (median, 13): 4 to 12 (median, 6) mutations in the RT gene, and 4 to 8 (median, 7) mutations in theprotease gene. In the RT gene, the most frequent resistance mutations werefound at codons 215 (100%), 41 (95%), 67 (91%), and 210 (77%). Multidrug-resistant mutation patterns including Q151M and insertion mutations at codon69, which confer cross-resistance to the different nucleoside analogue RT inhibitors were detected in 1 and 3 patients, respectively; 1 patient with insertion mutation displayed a NGQCV sequence at codons 67 to 70. In the protease gene, the most frequent mutations were found at codons 63 (95%), 10 (86%), 90(86%), 71(77%), 46 (50%), 36 (45%), and 84 (45%). Genotypic resistance to zidovudine, saquinavir, and indinavir was found in 100% of the patients. All patients showed also resistance or possible resistance to stavudine, abacavir, ritonavir, and nelfinavir. Mutations conferring genotypic resistance to nonnucleoside analogue RT inhibitors (NNRTIs) were found in 12 (80%) of the NNRTI-experienced patients and 1 of 7 NNRTI-naive patients. Ourresults indicate that failure of HAART in the patients extensively pretreated results from the multiplicity of RT and protease mutations that confer genotypic resistance to almost all available antiretroviral drugs. In thesepatients, genotypic resistance tests confirm the lack of alternative salvage therapy strategies based on the currently available antiretroviral drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:26:20