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Titolo:
Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin
Autore:
Kitano, S; Irimura, K; Sasaki, T; Abe, N; Baba, A; Miyake, Y; Katunuma, N; Yamamoto, K;
Indirizzi:
Taisho Pharmaceut Co Ltd, Pharmacol Res Lab, Kawauchi, Tokushima 7710194, Japan Taisho Pharmaceut Co Ltd Kawauchi Tokushima Japan 7710194 7710194, Japan Taisho Pharmaceut Co Ltd, Tokushima Res Ctr, Drug Safety Res Lab, Kawauchi, Tokushima 7710194, Japan Taisho Pharmaceut Co Ltd Kawauchi Tokushima Japan 7710194 7710194, Japan Kyushu Univ, Fac Dent, Dept Pharmacol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ol, Higashi Ku, Fukuoka 8128582, Japan Univ Tokushima, Sch Dent, Dept Microbiol, Tokushima 7708504, Japan Univ Tokushima Tokushima Japan 7708504 crobiol, Tokushima 7708504, Japan Tokushima Bunri Univ, Inst Hlth Sci, Yamashiro, Tokushima 7708514, Japan Tokushima Bunri Univ Yamashiro Tokushima Japan 7708514 ima 7708514, Japan
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 85, anno: 2001,
pagine: 84 - 91
SICI:
0021-5198(200101)85:1<84:SOGIIB>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALVEOLAR BONE LOSS; BACTEROIDES-GINGIVALIS; CYSTEINE PROTEINASE; ARG-GINGIPAIN; PERIODONTAL-DISEASE; GNOTOBIOTIC-RATS; LYS-GINGIPAIN; VIRULENCE; STRAINS; MUTANTS;
Keywords:
Arg-gingipain; Lys-gingipain; gingivitis; leupeptin; Porphyromonas gingivalis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kitano, S Taisho Pharmaceut Co Ltd, Pharmacol Res Lab, 224-2 Ebisuo, Kawauchi, Tokushima 7710194, Japan Taisho Pharmaceut Co Ltd 224-2 Ebisuo Kawauchi Tokushima Japan 7710194
Citazione:
S. Kitano et al., "Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin", JPN J PHARM, 85(1), 2001, pp. 84-91

Abstract

In this study, we developed a procedure to produce gingivitis in rats by inoculation of Porphyromonas gingivalis and studied the contribution of the bacterial cysteine proteinases, Arg-gingipain (Rgp) and Lys-gingipain (Kgp), to the pathology in the gingiva. To adhere the bacterium to periodontal tissues, a cotton thread was inserted between the first and second molar of right maxillary sites of rats. Rats in group A were administered with vehicle alone after bacterial (strain W83) inoculation. In group B, the bacteriawere inoculated in combination with leupeptin, a potent inhibitor of Rgp and Kgp, and then leupeptin alone was administered the week after. Rats in group C were administered leupeptin for 6 weeks after bacteria inoculation. All left maxillary gingiva in three groups showed no inflammatory changes. Right maxillary gingiva of group A showed most of the clinical landmarks ofgingivitis. Leupeptin exhibited only a little inhibitory effect on this gingivitis in group B, whereas it had a strong inhibitory effect on the inflammation in group C. These results suggest that P. gingivalis-induced gingivitis is attributable to Rgp and Kgp and that leupeptin is more effective inthe late phase than the early stage of gingivitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:37:34