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Titolo:
Prospects for research for disorders of the endocrine system
Autore:
Wilson, JD;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 r, Dept Internal Med, Dallas, TX 75390 USA
Titolo Testata:
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
fascicolo: 5, volume: 285, anno: 2001,
pagine: 624 - 627
SICI:
0098-7484(20010207)285:5<624:PFRFDO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE RECEPTOR; THYROTROPIN RECEPTOR; PRECOCIOUS PUBERTY; THYROID-HORMONE; MUTATIONS; AUTOANTIBODIES; RESISTANCE; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Wilson, JD Univ Texas, SW Med Ctr, Dept Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 75390 USA
Citazione:
J.D. Wilson, "Prospects for research for disorders of the endocrine system", J AM MED A, 285(5), 2001, pp. 624-627

Abstract

Endocrine disorders, primarily diseases of the thyroid, parathyroids, pituitary, gonad, and adrenal glands, constitute a major health problem in all societies. As a result of improved insight into the diagnosis, pathophysiology, and molecular bases, it is now possible to diagnose the disorders earlier in their development, and the treatment of the deficiency states for most hormones is successful. Furthermore, with recognition that many of thesedisorders are either the consequence of single-gene mutations or have a major genetic component, it is now possible to diagnose affected fetuses and family members at risk. Therapies for the syndromes of hormone overproduction are less successful and frequently result in destruction of the endocrine organ involved, and the treatment of hormone resistance states is similarly unsatisfactory. These disorders are candidates for the development of superagonists/antagonists and gene therapies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:40:23