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Titolo:
Research opportunities and advances in lung disease
Autore:
Crystal, RG;
Indirizzi:
Cornell Univ, Weill Med Coll, Inst Med Genet, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Inst Med Genet, New York, NY 10021 USA
Titolo Testata:
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
fascicolo: 5, volume: 285, anno: 2001,
pagine: 612 - 618
SICI:
0098-7484(20010207)285:5<612:ROAAIL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER RESPIRATORY-TRACT; CYSTIC-FIBROSIS GENE; ALPHA-1-ANTITRYPSIN DEFICIENCY; ELASTASE DEFENSES; MEDICAL PROGRESS; THERAPY; IDENTIFICATION; ADENOVIRUS; AEROSOL; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Crystal, RG Cornell Univ, Weill Med Coll, Inst Med Genet, 520 E 70th St,Suite 505, NewYork, NY 10021 USA Cornell Univ 520 E 70th St,Suite 505 New York NY USA 10021 USA
Citazione:
R.G. Crystal, "Research opportunities and advances in lung disease", J AM MED A, 285(5), 2001, pp. 612-618

Abstract

Lung diseases cause morbidity, mortality, and economic burden. Susceptibility to pathogenesis of most lung diseases result from a complex interactionof a relevant challenge from the environment, genetic background, and the nature of the host responses. Cutting-edge research in lung disease now centers on understanding the lung as a genetically determined biological organthat functions to mediate gas exchange and defend against a hostile environment. A major challenge is to determine the hierarchy of gene expression that integrates the function of multiple cell types in this complex anatomy. Emerging therapies that will play a major role in the future treatment of lung disease include the use of recombinant proteins. including monoclonal antibodies, cell therapy (including stem cells), and gene therapy. Future advances will include the cure of the major hereditary lung disorders by gene therapy, new treatment for asthma, chronic obstructive pulmonary disease,and interstitial lung disease; development of vaccines to protect the lungfrom major lung pathogens; and pathogen-specific "designer" therapies to eradicate chronic lung infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:31:09