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Titolo:
Effects of the soluble low-molecular-mass proteins on spleen activity and cellular composition of infiltrates in rat mammary gland tumors
Autore:
Kossoy, G; Ben-Hur, H; Kossoy, N; Zusman, I;
Indirizzi:
Hebrew Univ Jerusalem, Koret Sch Vet Med, Expt Oncol Lab, Fac Agr Food & Environm Qual Sci, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel Kaplan Med Ctr, Dept Obstet & Gynecol, Rehovot, Israel Kaplan Med Ctr Rehovot Israel r, Dept Obstet & Gynecol, Rehovot, Israel
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 221 - 224
SICI:
1107-3756(200102)7:2<221:EOTSLP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; IMMUNE-RESPONSE; COLON-CANCER; GENE-THERAPY; ANTIGEN; GROWTH; VACCINATION; EXPRESSION; CARCINOMA; MODEL;
Keywords:
lymphoid elements; macrophages; mammary gland tumors; tumor-associated antigens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Zusman, I Hebrew Univ Jerusalem, Koret Sch Vet Med, Expt Oncol Lab, Fac Agr Food & Environm Qual Sci, POB 12, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem POB 12 Rehovot Israel IL-76100 ot, Israel
Citazione:
G. Kossoy et al., "Effects of the soluble low-molecular-mass proteins on spleen activity and cellular composition of infiltrates in rat mammary gland tumors", INT J MOL M, 7(2), 2001, pp. 221-224

Abstract

We showed previously that soluble low-molecular-mass tumor-associated antigens (TAA) could suppress chemically-induced tumorigenesis. In this study, we analyzed the mechanism of those findings. Studies were performed on the spleen and mammary grand tumors obtained from the following groups of rats:i) control rats treated with dimethylbenz(alpha )antracene (DMBA), ii) vaccinated and carcinoentreated rats with non regressed tumors, iii) vaccinated and carcinogen-treated rats with regressed tumors. Different zones of thespleen and tumors and their cellular content (Ki67(+) and CD8(+) cells, and macrophages) were analyzed morphometrically and immunohistochemically. Reaction of the spleen to vaccination was manifested in a significant increase in all areas of the white pulp and in a decrease in the size of the red pulp. The total number of cells in the white pulp (germinal center and PALS)and in the marginal zone was significantly higher in the spleen of rats with regressed tumors. The number of Ki67(+) cells decreased significantly inboth groups of vaccinated rats, but most prominently in the marginal zone and the red pulp in rats with regressed tumors. An increased number of CD8() lymphocytes and macrophages was also seen in the red pulp. Different areas of the tumors (peripheral vs, inside at depth) showed different responses to vaccination and this difference was related to conditions of carcinogenesis, i.e. non-regressed vs, regressed tumors. In regressed tumors, all parameters studied were easily distinguishable in both areas of the tumors, while in non-regressed tumors, a marked distinction was seen only at their periphery. In regressed tumors, a negative correlation was seen at depth tumors between the number of Ki67(+) cells and the number of CD8(+) lymphocytes (r=-0.48). The findings indicated a strict antitumor effect of vaccination with the soluble low-molecular-mass TAA, which prevents the development of insufficiency of the immune system when an intensive immune reaction takes place.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:35:04