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Titolo:
Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives
Autore:
Okamoto, T; Yoshida, S; Kobayashi, T; Okabe, S;
Indirizzi:
Nippon Chemiphar Co Ltd, Res Labs, Misato, Saitama 3410005, Japan Nippon Chemiphar Co Ltd Misato Saitama Japan 3410005 itama 3410005, Japan Kyoto Pharmaceut Univ, Dept Appl Pharmacol, Kyoto 6078414, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078414 harmacol, Kyoto 6078414, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 177 - 180
SICI:
1107-3756(200102)7:2<177:IOAAMH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER; COUMARINS;
Keywords:
Fas; hepatitis; coumarin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Okamoto, T Nippon Chemiphar Co Ltd, Res Labs, 1-22 Hikokawato, Misato, Saitama 3410005, Japan Nippon Chemiphar Co Ltd 1-22 Hikokawato Misato Saitama Japan 3410005
Citazione:
T. Okamoto et al., "Inhibition of anti-Fas antibody-induced mice hepatitis by furocoumarin derivatives", INT J MOL M, 7(2), 2001, pp. 177-180

Abstract

The effects of imperatorin and its synthetic derivative, Y355, on anti-Fasantibody-induced mice hepatitis were studied. Pretreatment of mice by intraperitoneal administration of imperatorine or Y355 at 30 mg/kg inhibited more than 80% of the anti-Fas antibody (150 mug/kg, i.v.) induced elevation of plasma alanine aminotransferase activity. Furthermore, Oral administration of imperatorin or Y355 at 100 mg/kg also had an inhibitory effect on anti-Fas antibody-induced hepatitis. Both compounds inhibited anti-Fas antibody(250 mug/kg)-induced caspase-1 and caspase-3 activities. The present results showed the inhibition of anti-Fas antibody-induced hepatitis by imperatorin and Y355, which might be a result of inhibition of caspase activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:05:16