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Titolo:
Impaired Ca2+-sequestration in dilated cardiomyopathy (Review)
Autore:
Lennon, NJ; Ohlendieck, K;
Indirizzi:
Natl Univ Ireland Univ Coll Dublin, Dept Pharmacol, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland Natl Univ Ireland Univ Coll Dublin Dublin Ireland 4 s, Dublin 4, Ireland
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 2, volume: 7, anno: 2001,
pagine: 131 - 141
SICI:
1107-3756(200102)7:2<131:ICIDC(>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC SARCOPLASMIC-RETICULUM; FAILING HUMAN MYOCARDIUM; STAGE HEART-FAILURE; FLUORESCENCE ENERGY-TRANSFER; CHANNEL RYANODINE RECEPTOR; CALCIUM-RELEASE CHANNELS; SKELETAL-MUSCLE; GENE-EXPRESSION; ULTRASTRUCTURAL-LOCALIZATION; NA+-CA2+ EXCHANGER;
Keywords:
Ca2+-ATPase; cardiac relaxation; dilated cardiomyopathy; heart failure; phospholamban; SERCA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Ohlendieck, K Natl Univ Ireland Univ Coll Dublin, Dept Pharmacol, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland Natl Univ Ireland Univ Coll Dublin Dublin Ireland 4 reland
Citazione:
N.J. Lennon e K. Ohlendieck, "Impaired Ca2+-sequestration in dilated cardiomyopathy (Review)", INT J MOL M, 7(2), 2001, pp. 131-141

Abstract

Excitation-contraction coupling is the process by which depolarisation of the myocardial surface membrane leads to the release of Ca2+-ions from the sarcoplasmic reticulum, inducing cardiac muscle contraction. This process is made possible by an elaborate system of ion-release, uptake and sequestration that controls the contraction and relaxation cycle of heart muscle fibres. The free intracellular Ca2+-concentration determines the contractile state of the myocardium, and the sequestration of Ca2+-ions into the lumen of the sarcoplasmic reticulum by the Ca2+-ATPase pump units represents a critical step towards the maintenance of normal Ca2+-cycling. The Ca2+-ATPase pump activity is regulated by phospholamban, a small 52-amino acid protein whose phosphorylation state dictates its inhibitory action on the pump. A large body of evidence points to the central role of abnormal Ca2+-ATPase-phospholamban interactions in pathophysiological heart conditions, thereby compromising the contractile state of the cardiac muscle cell. It has been shown that alterations in the oligomeric status of the Ca2+-ATPase and modified interactions between the Ca2+-pump and its regulatory subunit phospholamban underlie the contractile dysfunction that characterises certain forms of dilated cardiomyopathy. Hence, elucidation of interactions within physiological Ca2+-ATPase pump units in normal and diseased myocardium is a vital link in the development of improved diagnostic and therapeutic techniques for dealing with this elusive condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 16:17:26