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Titolo:
Effects of PMCA2 mutation on DPOAE amplitudes and latencies in deafwaddlermice
Autore:
Konrad-Martin, D; Norton, SJ; Mascher, KE; Tempel, BL;
Indirizzi:
Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 & Hearing Sci, Seattle, WA 98195 USA Univ Washington, Dept Otolaryngol & Head & Neck Surg, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 d & Neck Surg, Seattle, WA 98195 USA Univ Washington, Virginia Merrill Bloedel Hearing Res Ctr, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 aring Res Ctr, Seattle, WA 98195 USA Childrens Hosp & Reg Med Ctr, Seattle, WA 98105 USA Childrens Hosp & Reg Med Ctr Seattle WA USA 98105 , Seattle, WA 98105 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 151, anno: 2001,
pagine: 205 - 220
SICI:
0378-5955(200101)151:1-2<205:EOPMOD>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRODUCT OTOACOUSTIC EMISSIONS; ACOUSTIC-DISTORTION PRODUCTS; HAIR CELL ELECTROMOTILITY; COCHLEAR ORIGIN; 2F1-F2; EAR; RESPONSES; DEAFNESS; GERBIL; MODEL;
Keywords:
mutant mouse; distortion product otoacoustic emission; furosemide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Konrad-Martin, D Boys Town Natl Res Hosp, 555 N 30th St, Omaha, NE 68131 USA Boys Town Natl Res Hosp 555 N 30th St Omaha NE USA 68131
Citazione:
D. Konrad-Martin et al., "Effects of PMCA2 mutation on DPOAE amplitudes and latencies in deafwaddlermice", HEARING RES, 151(1-2), 2001, pp. 205-220

Abstract

The deafwaddler (dfw) mouse mutant is caused by a spontaneous mutation in the gene that encodes a plasma membrane Ca2+ ATPase (type 2), PMCA2 (Streetet al., 1998. Nat. Genet. 19, 390-394), which is expressed in cochlear andvestibular hair cells. Distortion product otoacoustic emission (DPOAE) amplitudes and latencies were examined in control mice, deafwaddler mutants: and controls treated with the drug furosemide, Furosemide causes a transientreduction of DPOAEs (Mills et al., 1993. J. Acoust. Sec. Am. 94, 2108-2122). We wanted to determine whether DPOAEs obtained in furosemide-treated mice were similar or different from results obtained in +/dfw mice. DPOAE amplitude and phase were measured as a function of f(2)/f(1) ratio. These data were converted into waveforms using inverse fast Fourier transform, and their average latency was used to estimate DPOAE group delay. Homozygous deafwaddlers did not produce DPOAEs. Heterozygous deafwaddlers (+/dfw) had increased DPOAE thresholds and reduced amplitudes at high frequencies, compared to controls. To the extent that DPOAEs depend on functional outer hair cells (OHCs), abnormal DPOAEs in +/dfw mice suggest that PMCA2 is important forOI-IC function at high frequencies. Similar to the effects of furosemide, the mutation reduced DPOAEs for low-level stimuli; in contrast to furosemide, the mutation altered DPOAEs elicited by high levels. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/11/20 alle ore 04:28:36