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Titolo:
Effects of alpha-tocopherol on cisplatin-induced ototoxicity in guinea pigs
Autore:
Teranishi, M; Nakashima, T; Wakabayaski, T;
Indirizzi:
Nagoya Univ, Sch Med, Dept Otorhinolaryngol, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ, Sch Med, Dept Cell Biol & Mol Pathol, Showa Ku, Nagoya, Aichi4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 wa Ku, Nagoya, Aichi4668550, Japan
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 151, anno: 2001,
pagine: 61 - 70
SICI:
0378-5955(200101)151:1-2<61:EOAOCO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE CISPLATIN; AUDITORY HAIR-CELLS; VITAMIN-E; SODIUM THIOSULFATE; ANTIOXIDANT SYSTEM; HYDROGEN-PEROXIDE; INDUCED DAMAGE; INNER-EAR; 4-METHYLTHIOBENZOIC ACID; ADENOSINE RECEPTORS;
Keywords:
alpha-tocopherol; cisplatin; guinea pig; ototoxicity; free radical;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Teranishi, M Nagoya Univ, Sch Med, Dept Otorhinolaryngol, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsurumai Cho Nagoya Aichi Japan 4668550 Japan
Citazione:
M. Teranishi et al., "Effects of alpha-tocopherol on cisplatin-induced ototoxicity in guinea pigs", HEARING RES, 151(1-2), 2001, pp. 61-70

Abstract

Cisplatin (CDDP), an antitumor agent widely used in the treatment of head and neck cancers, has dose-limiting side effects such as ototoxicity and nephrotoxicity. Recently, evidence has been accumulated to demonstrate that these side effects are closely related to oxidative stress. In the present study, we attempted to suppress CDDP-induced ototoxicity and nephrotoxicity in guinea pigs by administering a-tocopherol, a naturally occurring antioxidant. Hartley albino guinea pigs (250 similar to 300 g) were treated with CDDP (4 mg/kg intraperitoneally (I.P.)) for 3 days in the presence and absence of alpha -tocopherol (50 mg/kg I.P.) injection for 6 days. The combined treatment of animals with alpha -tocopherol distinctly improved the CDDP-induced side effects. These were: loss of Preyer's reflex at high frequencies; distinct elevation of auditory brain stem response threshold at 16 kHz; increased lipid peroxidation in the cochlea determined by the malondialdehyde-thiobarbituric acid method; substantial losses of outer hair cells in thebasal and second turns of the cochlea; fragmentation of nuclear DNA detected by the TUNEL method in cochlear hair cells and cells in the stria vascularis; and increases in serum BUN and Cr. These results strongly suggest that alpha -tocopherol suppresses CDDP-induced ototoxicity and nephrotoxicity via the suppression of the increased production of reactive oxygen species. (C) 2001 Elsevier Science B.V. Pill rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:52:09