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Titolo:
Effects of chronic stimulation on auditory nerve survival in ototoxically deafened animals
Autore:
Miller, AL;
Indirizzi:
Univ Michigan, Kresge Hearing Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ng Res Inst, Ann Arbor, MI 48109 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 151, anno: 2001,
pagine: 1 - 14
SICI:
0378-5955(200101)151:1-2<1:EOCSOA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACOCHLEAR ELECTRICAL-STIMULATION; PSYCHOPHYSICAL DETECTION THRESHOLDS; SPIRAL GANGLION NEURONS; STRENGTH-DURATION FUNCTIONS; ACROSS-SPECIES COMPARISONS; GROWTH-FACTOR DEPENDENCE; PROFOUND HEARING-LOSS; BRAIN-STEM RESPONSE; COCHLEAR BLOOD-FLOW; GUINEA-PIG COCHLEA;
Keywords:
guinea pig; kitten; chronic stimulation; spiral ganglion cell; cochlear implant; auditory nerve;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
129
Recensione:
Indirizzi per estratti:
Indirizzo: Miller, AL Univ Michigan, Kresge Hearing Res Inst, 1301 E Ann St, Ann Arbor, MI 48109USA Univ Michigan 1301 E Ann St Ann Arbor MI USA 48109 MI 48109USA
Citazione:
A.L. Miller, "Effects of chronic stimulation on auditory nerve survival in ototoxically deafened animals", HEARING RES, 151(1-2), 2001, pp. 1-14

Abstract

For almost 10 years, chronic stimulation has been known to affect spiral ganglion cell (SGC) survival in the deaf ear. However, the reported effects of chronic stimulation vary across preparations and studies. In this review, the effects of chronic stimulation on the deafened auditory periphery areexamined, and variables that may impact on the efficacy of chronic stimulation are identified. The effects of deafening on the unstimulated peripheral and central auditory system are also described, as the deafened, unstimulated system is the canvas upon which stimulation-mediated effects are imposed. Discrepancies in the effects of chronic stimulation across studies may be attributable in large part to the combined effects of the deafening method and the post-deafening delay prior to chronic stimulation, which vary across studies. Emphasis is placed on the need to consider the natural progression of SGC loss following deafening in the absence of chronic stimulation, as the rate of SGC loss almost certainly affects both the efficacy of stimulation? and the impact of any delay between deafening and initiation of stimulation. The differences across preparations complicate direct comparison of protective efficacy of stimulation. At the same timer these differences can be used to our advantage, aiding characterization of the effects of different factors on the efficacy of chronic stimulation as a neuroprotective intervention. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:32:15