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Titolo:
Expression of Ki-67 in cervical epithelial cells in preneoplastic lesions of patients with AIDS
Autore:
Calore, EE; Cavaliere, MJ; Calore, NMP; Dias, SD; Dos Santos, RP; Vilela-de-Almeida, L;
Indirizzi:
Univ Sao Paulo, Emilio Ribas Infectol Inst, Pathol Sect, BR-01246902 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-01246902 BC01246902 Sao Paulo, Brazil Univ Sao Paulo, Adolfo Lutz Inst, Div Pathol, BR-01246902 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-01246902 BC01246902 Sao Paulo, Brazil
Titolo Testata:
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
fascicolo: 1, volume: 51, anno: 2001,
pagine: 51 - 54
SICI:
0378-7346(2001)51:1<51:EOKICE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SQUAMOUS INTRAEPITHELIAL LESIONS; UTERINE CERVIX; SEROPOSITIVE WOMEN; NEOPLASIA; PAPILLOMAVIRUS; ANTIGEN; ABNORMALITIES; FREQUENCY; APOPTOSIS;
Keywords:
AIDS; cervical intraepithelial lesions; cell proliferation markers; Ki-67 antigen; human papillomavirus; HIV; cervical carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Calore, EE Univ Sao Paulo, Emilio Ribas Infectol Inst, Pathol Sect, Av Dr Arnaldo 165, BR-01246902 Sao Paulo, Brazil Univ Sao Paulo Av Dr Arnaldo 165Sao Paulo Brazil BR-01246902 BC
Citazione:
E.E. Calore et al., "Expression of Ki-67 in cervical epithelial cells in preneoplastic lesions of patients with AIDS", GYNECOL OBS, 51(1), 2001, pp. 51-54

Abstract

The objective of the present investigation was to study the expression of the proliferation marker Ki-67 in cervical intraepithelial lesions in womenwith AIDS. We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (HI-GIN) in AIDS patients and 18 Lo-CIN and 14 HI-GIN in patients from the general population. Positive Ki-67 nuclei were counted. A significantly higher number of Ki-67-positive cells (p < 0.001) was found in Lo-CIN of AIDS patients (mean 29.18 +/- 10.44) as compared with Lo-CIN of general-population women (mean 17.08 +/- 7.40), whereas no significant difference in positive Ki-67 nuclei was observed in the HI-GIN of AIDS patients and of patients from the general population (p > 0.05), We conclude that the proliferative potential of cervicalcells in Lo-CIN - as studied by the expression of the proliferation markerKi-67 - is higher in AIDS patients than in the general population. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 03:01:04