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Titolo:
Maternal plasma leptin levels and their relationship to insulin and glucose in gestational-onset diabetes
Autore:
Vitoratos, N; Salamalekis, E; Kassanos, D; Loghis, C; Panayotopoulos, N; Kouskouni, E; Creatsas, G;
Indirizzi:
Univ Athens, Dept Obstet & Gynecol 2, Areteion Hosp, GR-11528 Athens, Greece Univ Athens Athens Greece GR-11528 reteion Hosp, GR-11528 Athens, Greece
Titolo Testata:
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
fascicolo: 1, volume: 51, anno: 2001,
pagine: 17 - 21
SICI:
0378-7346(2001)51:1<17:MPLLAT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE-EXPRESSION; CIRCULATING LEPTIN; ADIPOSE-TISSUE; CORD-BLOOD; OB GENE; PREGNANCY; HUMANS; WEIGHT; SERUM; WOMEN;
Keywords:
leptin; gestational-onset diabetes; insulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Vitoratos, N Univ Athens, Dept Obstet & Gynecol 2, Areteion Hosp, 76 Vas Sophias Ave, GR-11528 Athens, Greece Univ Athens 76 Vas Sophias Ave Athens Greece GR-11528 Greece
Citazione:
N. Vitoratos et al., "Maternal plasma leptin levels and their relationship to insulin and glucose in gestational-onset diabetes", GYNECOL OBS, 51(1), 2001, pp. 17-21

Abstract

To investigate the changes in leptin levels and the relationship between this substance and insulin and glucose in pregnant women with gestational-onset diabetes, we measured plasma leptin levels in the maternal peripheral vein of 17 healthy and 17 diabetic women at 29 and 33 weeks of gestation, Wealso correlated maternal plasma leptin levels in diabetic women with fasting plasma insulin levels and plasma glucose levels obtained 1 h after oral administration of 50 g of glucose. Maternal serum leptin levels in women with gestational diabetes (mean +/- SD 16.52 +/- 5.07 ng/ml, range 10.84-27.4ng/ml) were significantly higher (p < 0.001) than those found in uncomplicated pregnancies (10.61 +/- 1.47 ng/ml, range 7.28-13.4 ng/ml). A positive correlation was found between maternal serum leptin levels and glycosylatedhaemoglobin values in diabetic pregnant women (r = 0.94, p < 0.001). A positive correlation was also found between maternal leptin concentrations andfasting serum insulin levels, as well as between leptin concentrations andplasma glucose levels obtained 1 h after the administration of 50 g of glucose in women with gestational diabetes (r = 0.84, p < 0.001, and r = 0.92,p < 0.001, respectively). We conclude that leptin levels are elevated in pregnant women with gestational diabetes, and its metabolism depends on insulin levels and the severity of diabetes. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:00:33